Gastric cancer (GC) ranks fifth in global cancer diagnosis and fourth in cancer-related death.
Despite tremendous progress in diagnosis and therapeutic strategies and significant …

The Ras/Raf/extracellular signal‐regulated kinase (ERK) signaling pathway plays a crucial
role in almost all cell functions and therefore requires exquisite control of its spatiotemporal …

Sequential activation of kinases within the mitogen-activated protein (MAP) kinase (MAPK)
cascades is a common, and evolutionary-conserved mechanism of signal transduction. Four …

Understanding the molecular mechanisms underlying synergistic, potentiative and
antagonistic effects of drug combinations could facilitate the discovery of novel efficacious …

Programmed cell death is a basic cellular mechanism. Apoptotic-like programmed cell death
(called apoptosis in animals) occurs in both unicellular and multicellular eukaryotes, and …

Cancer is one of the leading causes of death and significantly burdens the healthcare
system. Due to its prevalence, there is undoubtedly an unmet need to discover novel …

Cells that cannot satisfy the spindle assembly checkpoint (SAC) are delayed in mitosis (D-
mitosis), a fact that has useful clinical ramifications. However, this delay is seldom …

To investigate the role of an activated K-Ras gene in the initiation and maintenance of lung
adenocarcinomas, we developed transgenic mice that express murine K-Ras4b G12D …

Microtubules are highly dynamic cellular polymers made of αβ-tubulin and associated
proteins. They play a key role during mitosis, participating in the exact organization and …

Background The status of human epidermal growth factor receptor type 2 (HER2) in breast-
cancer cells predicts clinical outcomes in women who receive adjuvant anthracycline-based …