Targeted therapeutic options and future perspectives for HER2-positive breast cancer
J Wang, B Xu - Signal transduction and targeted therapy, 2019 - nature.com
Over the past 2 decades, there has been an extraordinary progress in the regimens
developed for the treatment of human epidermal growth factor receptor 2 (HER2)-positive …
developed for the treatment of human epidermal growth factor receptor 2 (HER2)-positive …
Targeting cell cycle in breast cancer: CDK4/6 inhibitors
Deregulation of cell cycle, via cyclin D/CDK/pRb pathway, is frequently observed in breast
cancer lending support to the development of drugs targeting the cell cycle control …
cancer lending support to the development of drugs targeting the cell cycle control …
[HTML][HTML] Mechanism, safety and efficacy of three tyrosine kinase inhibitors lapatinib, neratinib and pyrotinib in HER2-positive breast cancer
JC Xuhong, XW Qi, Y Zhang, J Jiang - American journal of cancer …, 2019 - ncbi.nlm.nih.gov
The incidence of breast cancer ranks first among female malignant tumors that affect
women's health. Epidermal growth factor receptor (EGFR) family overexpression, especially …
women's health. Epidermal growth factor receptor (EGFR) family overexpression, especially …
Tyrosine kinase inhibitors in breast cancer
Anti‑epidermal growth factor receptor (EGFR)‑targeted therapy has been intensely
researched in the last years, motivated by the favorable results obtained with monoclonal …
researched in the last years, motivated by the favorable results obtained with monoclonal …
DNA damage induced by CDK4 and CDK6 blockade triggers anti-tumor immune responses through cGAS-STING pathway
H Fan, W Liu, Y Zeng, Y Zhou, M Gao, L Yang… - Communications …, 2023 - nature.com
CDK4/6 are important regulators of cell cycle and their inhibitors have been approved as
anti-cancer drugs. Here, we report a STING-dependent anti-tumor immune mechanism …
anti-cancer drugs. Here, we report a STING-dependent anti-tumor immune mechanism …
Direct C3 Alkoxylation of Quinoxalin-2(1H)-ones with Alcohols via Cross-Dehydrogenative Coupling under Catalyst-Free Conditions
Q Yang, X Han, J Zhao, HY Zhang… - The Journal of Organic …, 2019 - ACS Publications
A facile and effective alkoxylation protocol of quinoxalin-2 (1 H)-ones with primary or
secondary alcohols via cross-dehydrogenative coupling under catalyst-free conditions has …
secondary alcohols via cross-dehydrogenative coupling under catalyst-free conditions has …
CDK4/6 and MAPK—crosstalk as opportunity for cancer treatment
L Scheiblecker, K Kollmann, V Sexl - Pharmaceuticals, 2020 - mdpi.com
Despite the development of targeted therapies and novel inhibitors, cancer remains an
undefeated disease. Resistance mechanisms arise quickly and alternative treatment options …
undefeated disease. Resistance mechanisms arise quickly and alternative treatment options …
Novel therapies and strategies to overcome resistance to anti-HER2-targeted drugs
M Gámez-Chiachio, D Sarrió, G Moreno-Bueno - Cancers, 2022 - mdpi.com
Simple Summary Drug resistance is the “Achilles' heel” in current oncology. In this sense,
the clinical management of HER2 breast carcinomas (tumors with overexpression …
the clinical management of HER2 breast carcinomas (tumors with overexpression …
Modulation of the estrogen/erbb2 receptors cross-talk by cdk4/6 inhibition triggers sustained senescence in estrogen receptor–and erbb2-positive breast cancer
L Viganò, A Locatelli, A Ulisse, B Galbardi, M Dugo… - Clinical Cancer …, 2022 - AACR
Purpose: The interplay between estrogen receptor (ER) and erbB tyrosine-kinase receptors
(RTK) impacts growth and progression of ER-positive (ER+)/HER2-positive (HER2+) breast …
(RTK) impacts growth and progression of ER-positive (ER+)/HER2-positive (HER2+) breast …
The C3-H Bond Functionalization of Quinoxalin-2(1H)-Ones With Hypervalent Iodine(III) Reagents
Y Tan, J Wang, HY Zhang, Y Zhang, J Zhao - Frontiers in Chemistry, 2020 - frontiersin.org
The modification of quinoxalin-2 (1 H)-ones via direct CH bond functionalization has begun
to receive widespread attention, due to quinoxalin-2 (1 H)-one derivatives' various biological …
to receive widespread attention, due to quinoxalin-2 (1 H)-one derivatives' various biological …