Advancements in next-generation sequencing and other-omics technologies are
accelerating the detailed molecular characterization of individual patient tumors, and driving …

Context.—Clinical next-generation sequencing (NGS) is being rapidly adopted, but analysis
and interpretation of large data sets prompt new challenges for a clinical laboratory setting …

The extent to which gene fusions function as drivers of cancer remains a critical open
question. Current algorithms do not sufficiently identify false-positive fusions arising during …

Precise splice junction calls are currently unavailable in scRNA-seq pipelines such as the
10x Chromium platform but are critical for understanding single-cell biology. Here, we …

Fusion genes, playing a causal role in human tumorigenesis and developments, are
deemed as gold standard molecular biomarkers in cancer diagnosis, therapy, and …

A significant proportion of infant B-cell acute lymphoblastic leukemia (B-ALL) patients
remains with a dismal prognosis due to yet undetermined mechanisms. We performed a …

As causative oncogenes and drug targets, fusion genes play critical roles in tumorigenesis,
development, and treatment and thus are regarded as tumor-specific molecular biomarkers …

Cell free nucleic acids from a test sample obtained from an individual are analyzed to
identify possible fusion events. Cell free nucleic acids are sequenced and processed to …

Recurrent chromosomal translocations, known as fusions, play important roles in
carcinogenesis. They can serve as valuable diagnostic and therapeutic targets. RNA-seq is …

The burden of foodborne diseases is heavy, which comes from all age groups and
individuals in all regions. A person who is eating may be subject to microbial or chemical …