S-Adenosylmethionine: more than just a methyl donor
Covering: from 2000 up to the very early part of 2023 S-Adenosyl-L-methionine (SAM) is a
naturally occurring trialkyl sulfonium molecule that is typically associated with biological …
naturally occurring trialkyl sulfonium molecule that is typically associated with biological …
Antimicrobial nucleoside antibiotics targeting cell wall assembly: Recent advances in structure–function studies and nucleoside biosynthesis
Covering: 2003 to 2009 The quest for new antibiotics, especially those with activity against
Gram-negative bacteria, is urgent; however, very few new antibiotics have been marketed in …
Gram-negative bacteria, is urgent; however, very few new antibiotics have been marketed in …
Heteroatom–heteroatom bond formation in natural product biosynthesis
Natural products that contain functional groups with heteroatom-heteroatom linkages (X–X,
where X= N, O, S, and P) are a small yet intriguing group of metabolites. The reactivity and …
where X= N, O, S, and P) are a small yet intriguing group of metabolites. The reactivity and …
Recent advances in the discovery and development of marine microbial natural products
Marine microbial natural products (MMNPs) have attracted increasing attention from
microbiologists, taxonomists, ecologists, agronomists, chemists and evolutionary biologists …
microbiologists, taxonomists, ecologists, agronomists, chemists and evolutionary biologists …
Nucleoside antibiotics: biosynthesis, regulation, and biotechnology
G Niu, H Tan - Trends in microbiology, 2015 - cell.com
The alarming rise in antibiotic-resistant pathogens has coincided with a decline in the supply
of new antibiotics. It is therefore of great importance to find and create new antibiotics …
of new antibiotics. It is therefore of great importance to find and create new antibiotics …
Identification of the biosynthetic gene cluster for the pacidamycin group of peptidyl nucleoside antibiotics
Pacidamycins are a family of uridyl tetra/pentapeptide antibiotics that act on the translocase
MraY to block bacterial cell wall assembly. To elucidate the biosynthetic logic of …
MraY to block bacterial cell wall assembly. To elucidate the biosynthetic logic of …
Amalgamation of Nucleosides and Amino Acids in Antibiotic Biosynthesis: Discovery of an l-Threonine:Uridine-5′-Aldehyde Transaldolase
S Barnard-Britson, X Chi, K Nonaka… - Journal of the …, 2012 - ACS Publications
The lipopeptidyl nucleoside antibiotics represented by A-90289, caprazamycin, and
muraymycin are structurally highlighted by a nucleoside core that contains a …
muraymycin are structurally highlighted by a nucleoside core that contains a …
Biosynthesis of the tunicamycin antibiotics proceeds via unique exo-glycal intermediates
FJ Wyszynski, SS Lee, T Yabe, H Wang… - Nature …, 2012 - nature.com
The tunicamycins are archetypal nucleoside antibiotics targeting bacterial peptidoglycan
biosynthesis and eukaryotic protein N-glycosylation. Understanding the biosynthesis of their …
biosynthesis and eukaryotic protein N-glycosylation. Understanding the biosynthesis of their …
Function-oriented synthesis of simplified caprazamycins: discovery of oxazolidine-containing uridine derivatives as antibacterial agents against drug-resistant bacteria
K Ii, S Ichikawa, B Al-Dabbagh, A Bouhss… - Journal of medicinal …, 2010 - ACS Publications
The rational simplification of the caprazamycin (CPZ) class of nucleoside natural products
was carried out to address their molecular complexity. First, analogues 6− 8, where the …
was carried out to address their molecular complexity. First, analogues 6− 8, where the …
Pyridoxal-5′-phosphate-dependent alkyl transfer in nucleoside antibiotic biosynthesis
Several nucleoside antibiotics are structurally characterized by a 5 ″-amino-5 ″-
deoxyribose (ADR) appended via a glycosidic bond to a high-carbon sugar nucleoside (5 …
deoxyribose (ADR) appended via a glycosidic bond to a high-carbon sugar nucleoside (5 …