Intrinsic structural disorder in adenovirus E1A: a viral molecular hub linking multiple diverse processes
Viruses are obligate intracellular parasites. Their genomes are not large enough to encode
all the functions required to independently produce progeny; hence, viruses are absolutely …
all the functions required to independently produce progeny; hence, viruses are absolutely …
[PDF][PDF] Adenovirus and cell cycle control
H Ben-Israel, T Kleinberger - Front Biosci, 2002 - researchgate.net
Introduction 3. The E1A proteins 3.1. Early findings 3.2. Targeting the pRb checkpoint by
E1A 3.2. 1. pRb 3.2. 2. pRb family members 3.3. Targeting cyclin-Cdks by E1A 3.4. E1A …
E1A 3.2. 1. pRb 3.2. 2. pRb family members 3.3. Targeting cyclin-Cdks by E1A 3.4. E1A …
Aberrant regulation of survivin by the RB/E2F family of proteins
Y Jiang, HI Saavedra, MP Holloway, G Leone… - Journal of Biological …, 2004 - ASBMB
Survivin is a putative oncogene that is aberrantly expressed in cancer cells. It has been
hypothesized to play a central role in cancer progression and resistance to therapy in …
hypothesized to play a central role in cancer progression and resistance to therapy in …
Np95 is regulated by E1A during mitotic reactivation of terminally differentiated cells and is essential for S phase entry
Terminal differentiation exerts a remarkably tight control on cell proliferation. However, the
oncogenic products of DNA tumor viruses, such as adenovirus E1A, can force postmitotic …
oncogenic products of DNA tumor viruses, such as adenovirus E1A, can force postmitotic …
[HTML][HTML] Comprehensive sequence analysis of the E1A proteins of human and simian adenoviruses
N Avvakumov, AE Kajon, RC Hoeben, JS Mymryk - Virology, 2004 - Elsevier
Despite extensive study of human adenovirus type 5 E1A, surprisingly little is known about
the E1A proteins of other adenoviruses. We report here a comprehensive analysis of the …
the E1A proteins of other adenoviruses. We report here a comprehensive analysis of the …
Proto-oncogene activity of melanoma antigen-A11 (MAGE-A11) regulates retinoblastoma-related p107 and E2F1 proteins
S Su, JT Minges, G Grossman, AJ Blackwelder… - Journal of Biological …, 2013 - ASBMB
Melanoma antigen-A11 (MAGE-A11) is a low-abundance, primate-specific steroid receptor
coregulator in normal tissues of the human reproductive tract that is expressed at higher …
coregulator in normal tissues of the human reproductive tract that is expressed at higher …
Adenoviruses with Tcf binding sites in multiple early promoters show enhanced selectivity for tumour cells with constitutive activation of the wnt signalling pathway
Mutation of the adenomatous polyposis coli and β-catenin genes in colon cancer leads to
constitutive activation of transcription from promoters containing binding sites for Tcf/LEF …
constitutive activation of transcription from promoters containing binding sites for Tcf/LEF …
[HTML][HTML] Oncolytic virotherapy
Current oncolytic virotherapy strategies are based in the accumulated understanding of the
common molecular mechanisms displayed during cell transformation and viral infection, like …
common molecular mechanisms displayed during cell transformation and viral infection, like …
Rapamycin inhibits human in stent restenosis vascular smooth muscle cells independently of pRB phosphorylation and p53
Objective: Drug-eluting stents containing the immunosuppressant rapamycin markedly
inhibit in stent restenosis (ISR). However, the molecular mechanisms that underlie its effect …
inhibit in stent restenosis (ISR). However, the molecular mechanisms that underlie its effect …
Cancer markers
PP Di Fiore, S Pece - US Patent 7,901,876, 2011 - Google Patents
2007-04-19 Assigned to IFOM FONDAZIONE INSTITUTO FIRC DI ONCOLOGIA
MOLECOLARE reassignment IFOM FONDAZIONE INSTITUTO FIRC DI ONCOLOGIA …
MOLECOLARE reassignment IFOM FONDAZIONE INSTITUTO FIRC DI ONCOLOGIA …