Neutrophil phenotypes and functions in cancer: A consensus statement

DF Quail, B Amulic, M Aziz, BJ Barnes… - Journal of Experimental …, 2022 - rupress.org
Neutrophils are the first responders to infection and inflammation and are thus a critical
component of innate immune defense. Understanding the behavior of neutrophils as they …

Systemic immunity in cancer

KJ Hiam-Galvez, BM Allen, MH Spitzer - Nature reviews cancer, 2021 - nature.com
Immunotherapy has revolutionized cancer treatment, but efficacy remains limited in most
clinical settings. Cancer is a systemic disease that induces many functional and …

Tumour-associated neutrophils in patients with cancer

ME Shaul, ZG Fridlender - Nature reviews Clinical oncology, 2019 - nature.com
The role and importance of neutrophils in cancer has become increasingly apparent over
the past decade. Neutrophils accumulate in the peripheral blood of patients with cancer …

[HTML][HTML] Neutrophil: a cell with many roles in inflammation or several cell types?

C Rosales - Frontiers in physiology, 2018 - frontiersin.org
Neutrophils are the most abundant leukocytes in the circulation, and have been regarded as
first line of defense in the innate arm of the immune system. They capture and destroy …

Neutrophil plasticity in the tumor microenvironment

MA Giese, LE Hind… - Blood, The Journal of the …, 2019 - ashpublications.org
Neutrophils act as the body's first line of defense against infection and respond to diverse
inflammatory cues, including cancer. Neutrophils display plasticity, with the ability to adapt …

Neutrophil diversity in health and disease

C Silvestre-Roig, ZG Fridlender, M Glogauer… - Trends in …, 2019 - cell.com
New evidence has challenged the outdated dogma that neutrophils are a homogeneous
population of short-lived cells. Although neutrophil subpopulations with distinct functions …

Neutrophils at the crossroads of innate and adaptive immunity

C Rosales - Journal of Leucocyte Biology, 2020 - academic.oup.com
Neutrophils are the most abundant leukocytes in blood. From the circulation, they are quickly
mobilized to sites of inflammation and/or infection. At the affected tissues, neutrophils display …

[HTML][HTML] Potential roles and targeted therapy of the CXCLs/CXCR2 axis in cancer and inflammatory diseases

Y Cheng, X Ma, Y Wei, XW Wei - … et Biophysica Acta (BBA)-Reviews on …, 2019 - Elsevier
The chemokine receptor CXCR2 and its ligands are implicated in the progression of tumours
and various inflammatory diseases. Activation of the CXCLs/CXCR2 axis activates multiple …

[HTML][HTML] Phenotypic diversity and plasticity in circulating neutrophil subpopulations in cancer

JY Sagiv, J Michaeli, S Assi, I Mishalian, H Kisos… - Cell reports, 2015 - cell.com
Controversy surrounds neutrophil function in cancer because neutrophils were shown to
provide both pro-and antitumor functions. We identified a heterogeneous subset of low …

Inhibition of MDSC trafficking with SX-682, a CXCR1/2 inhibitor, enhances NK-cell immunotherapy in head and neck cancer models

S Greene, Y Robbins, WK Mydlarz, AP Huynh… - Clinical Cancer …, 2020 - AACR
Abstract Purpose: Natural killer (NK)-cell–based immunotherapy may overcome obstacles to
effective T-cell–based immunotherapy such as the presence of genomic alterations in IFN …