Therapeutic vaccines represent a viable option for active immunotherapy of cancers that aim
to treat late stage disease by using a patient's own immune system. The promising results …

DNA vaccination has suddenly become a favoured strategy for inducing immunity. The
molecular precision offered by gene-based vaccines, together with the facility to include …

While showing promise, vaccination strategies to treat cancer require further optimization.
Likely barriers to efficacy involve cancer-associated immunosuppression and peripheral …

We are evaluating the use of electroporation (EP) to deliver a novel DNA vaccine, p. DOM-
PSMA27. This vaccine encodes a domain (DOM) of fragment C of tetanus toxin to induce …

Angiogenesis is increasingly recognized as an important prognosticator associated with the
progression of lymphoma and as an attractive target for novel modalities. We report a …

Delivery of antigens by injection of the encoding DNA allows access to multiple antigen-
presenting pathways. Knowledge of immunological processes can therefore be used to …

A large volume of data relevant to immunology research has accumulated due to
sequencing of genomes of the human and other model organisms. At the same time, huge …

Background Tumor endothelial marker 1 (TEM1) is a protein expressed in the tumor-
associated endothelium and/or stroma of various types of cancer. We previously …

The minor capsid protein L2 is a promising candidate for the construction of an anti-human
papillomavirus (HPV) broadly protective vaccine for the prophylaxis of cervical cancer …

We have developed novel DNA fusion vaccines encoding tumor Ags fused to pathogen-
derived sequences. This strategy activates linked T cell help and, using fragment C of tetnus …