Short-wave infrared confocal fluorescence imaging of deep mouse brain with a superconducting nanowire single-photon detector

F Xia, M Gevers, A Fognini, AT Mok, B Li, N Akbari… - Acs …, 2021 - ACS Publications
Optical microscopy is a valuable tool for in vivo monitoring of biological structures and
functions because of its noninvasiveness. However, imaging deep into biological tissues is …

Neurophotonic tools for microscopic measurements and manipulation: status report

AS Abdelfattah, S Ahuja, T Akkin, SR Allu… - …, 2022 - spiedigitallibrary.org
Neurophotonics was launched in 2014 coinciding with the launch of the BRAIN Initiative
focused on development of technologies for advancement of neuroscience. For the last …

Tutorial: multiphoton microscopy to advance neuroscience research

IC Hernández, J Yau, L Rishøj, N Cui… - … and Applications in …, 2023 - iopscience.iop.org
Multiphoton microscopy (MPM) employs ultrafast infrared lasers for high-resolution deep
three-dimensional imaging of live biological samples. The goal of this tutorial is to provide a …

Development of a beam propagation method to simulate the point spread function degradation in scattering media

X Cheng, Y Li, J Mertz, S Sakadžić, A Devor, DA Boas… - Optics letters, 2019 - opg.optica.org
Scattering is one of the main issues that limit the imaging depth in deep tissue optical
imaging. To characterize the role of scattering, we have developed a forward model based …

Comparing the fundamental imaging depth limit of two-photon, three-photon, and non-degenerate two-photon microscopy

X Cheng, S Sadegh, S Zilpelwar, A Devor, L Tian… - Optics letters, 2020 - opg.optica.org
We have systematically characterized the degradation of imaging quality with depth in deep
brain multi-photon microscopy, utilizing our recently developed numerical model that …

Efficient non-degenerate two-photon excitation for fluorescence microscopy

S Sadegh, MH Yang, CGL Ferri, M Thunemann… - Optics express, 2019 - opg.optica.org
Non-degenerate two-photon excitation (ND-TPE) has been explored in two-photon
excitation microscopy. However, a systematic study of the efficiency of ND-TPE to guide the …

Non-Degenerate Two-Photon Absorption of Fluorescent Protein Chromophores

IA Elayan, A Brown - The Journal of Physical Chemistry A, 2024 - ACS Publications
Two-photon absorption (2PA), where a pair of photons are absorbed simultaneously, is
recognized as a potent bioimaging technique, which depends on the quantified 2PA …

Measurement of the relative non-degenerate two-photon absorption cross-section for fluorescence microscopy

S Sadegh, MH Yang, CGL Ferri, M Thunemann… - Optics express, 2019 - opg.optica.org
In non-degenerate two-photon microscopy (ND-TPM), the required energy for fluorescence
excitation occurs via absorption of two photons of different energies derived from two …

[HTML][HTML] Passive, controllable generation of energetic multi-color pulses via spatial mode re-organizations in optical fibers

HB Kabagöz, A Antikainen, S Ramachandran - APL Photonics, 2021 - pubs.aip.org
Multi-color energetic pulses of fs pulse width are of interest to applications such as mid-IR
wavelength generation via difference frequency generation, nonlinear microscopy, and high …

Two-photon absorption properties of gold fluorescent protein: a combined molecular dynamics and quantum chemistry study

Y Simsek, A Brown - The Journal of Physical Chemistry B, 2018 - ACS Publications
Molecular dynamics (MD) simulations were carried out to obtain the conformational changes
of the chromophore in the gold fluorescent protein (PDB ID: 1OXF). To obtain two-photon …