Mechanisms and disease consequences of nonalcoholic fatty liver disease

R Loomba, SL Friedman, GI Shulman - Cell, 2021 - cell.com
Nonalcoholic fatty liver disease (NAFLD) is the leading chronic liver disease worldwide. Its
more advanced subtype, nonalcoholic steatohepatitis (NASH), connotes progressive liver …

Mechanisms of hepatic stellate cell activation

T Tsuchida, SL Friedman - Nature reviews Gastroenterology & …, 2017 - nature.com
Hepatic fibrosis is a dynamic process characterized by the net accumulation of extracellular
matrix resulting from chronic liver injury of any aetiology, including viral infection, alcoholic …

Fibrosis—a common pathway to organ injury and failure

DC Rockey, PD Bell, JA Hill - New England Journal of Medicine, 2015 - Mass Medical Soc
Fibrosis — A Common Pathway to Organ Injury and Failure | New England Journal of Medicine
Skip to main content The New England Journal of Medicine homepage Advanced Search …

[PDF][PDF] Current and future therapeutic regimens for nonalcoholic fatty liver disease and nonalcoholic steatohepatitis

ZM Younossi, R Loomba, ME Rinella, E Bugianesi… - …, 2018 - Wiley Online Library
Nonalcoholic fatty liver disease (NAFLD) and its progressive form non‐alcoholic
steatohepatitis (NASH), are rapidly becoming among the top causes of cirrhosis …

Application of artificial intelligence for the diagnosis and treatment of liver diseases

JC Ahn, A Connell, DA Simonetto, C Hughes… - …, 2021 - Wiley Online Library
Modern medical care produces large volumes of multimodal patient data, which many
clinicians struggle to process and synthesize into actionable knowledge. In recent years …

Advances in non-invasive assessment of hepatic fibrosis

R Loomba, LA Adams - Gut, 2020 - gut.bmj.com
Liver fibrosis should be assessed in all individuals with chronic liver disease as it predicts
the risk of future liver-related morbidity and thus need for treatment, monitoring and …

[PDF][PDF] Hepatic inflammation and fibrosis: functional links and key pathways

E Seki, RF Schwabe - Hepatology, 2015 - Wiley Online Library
Inflammation is one of the most characteristic features of chronic liver disease of viral,
alcoholic, fatty, and autoimmune origin. Inflammation is typically present in all disease …

[HTML][HTML] Artificial intelligence in gastroenterology: A state-of-the-art review

PT Kröner, MML Engels, BS Glicksberg… - World journal of …, 2021 - ncbi.nlm.nih.gov
The development of artificial intelligence (AI) has increased dramatically in the last 20 years,
with clinical applications progressively being explored for most of the medical specialties …

Fibrosis regression after eradication of hepatitis C virus: from bench to bedside

DC Rockey, SL Friedman - Gastroenterology, 2021 - Elsevier
Hepatitis C virus (HCV) infection and its complications have been the major cause of
cirrhosis and its complications for several decades in the Western world. Until recently …

[PDF][PDF] Applying machine learning in liver disease and transplantation: a comprehensive review

A Spann, A Yasodhara, J Kang, K Watt, BO Wang… - …, 2020 - Wiley Online Library
Machine learning (ML) utilizes artificial intelligence to generate predictive models efficiently
and more effectively than conventional methods through detection of hidden patterns within …