cGAS–STING drives ageing-related inflammation and neurodegeneration
MF Gulen, N Samson, A Keller, M Schwabenland… - Nature, 2023 - nature.com
Low-grade inflammation is a hallmark of old age and a central driver of ageing-associated
impairment and disease. Multiple factors can contribute to ageing-associated inflammation; …
impairment and disease. Multiple factors can contribute to ageing-associated inflammation; …
Senescence atlas reveals an aged-like inflamed niche that blunts muscle regeneration
Tissue regeneration requires coordination between resident stem cells and local niche
cells,. Here we identify that senescent cells are integral components of the skeletal muscle …
cells,. Here we identify that senescent cells are integral components of the skeletal muscle …
[HTML][HTML] Nonlinear dynamics of multi-omics profiles during human aging
Aging is a complex process associated with nearly all diseases. Understanding the
molecular changes underlying aging and identifying therapeutic targets for aging-related …
molecular changes underlying aging and identifying therapeutic targets for aging-related …
[HTML][HTML] ARDD 2020: from aging mechanisms to interventions
GV Mkrtchyan, K Abdelmohsen, P Andreux… - Aging (Albany …, 2020 - ncbi.nlm.nih.gov
Aging is emerging as a druggable target with growing interest from academia, industry and
investors. New technologies such as artificial intelligence and advanced screening …
investors. New technologies such as artificial intelligence and advanced screening …
Hallmarks of ageing in human skeletal muscle and implications for understanding the pathophysiology of sarcopenia in women and men
A Granic, K Suetterlin, T Shavlakadze… - Clinical …, 2023 - portlandpress.com
Ageing is a complex biological process associated with increased morbidity and mortality.
Nine classic, interdependent hallmarks of ageing have been proposed involving genetic and …
Nine classic, interdependent hallmarks of ageing have been proposed involving genetic and …
Mitochondrial dynamics maintain muscle stem cell regenerative competence throughout adult life by regulating metabolism and mitophagy
Skeletal muscle regeneration depends on the correct expansion of resident quiescent stem
cells (satellite cells), a process that becomes less efficient with aging. Here, we show that …
cells (satellite cells), a process that becomes less efficient with aging. Here, we show that …
Regulatory T cells shield muscle mitochondria from interferon-γ–mediated damage to promote the beneficial effects of exercise
Exercise enhances physical performance and reduces the risk of many disorders such as
cardiovascular disease, type 2 diabetes, dementia, and cancer. Exercise characteristically …
cardiovascular disease, type 2 diabetes, dementia, and cancer. Exercise characteristically …
Cell profiling of mouse acute kidney injury reveals conserved cellular responses to injury
Y Kirita, H Wu, K Uchimura… - Proceedings of the …, 2020 - National Acad Sciences
After acute kidney injury (AKI), patients either recover or alternatively develop fibrosis and
chronic kidney disease. Interactions between injured epithelia, stroma, and inflammatory …
chronic kidney disease. Interactions between injured epithelia, stroma, and inflammatory …
Aging is associated with a systemic length-associated transcriptome imbalance
Aging is among the most important risk factors for morbidity and mortality. To contribute
toward a molecular understanding of aging, we analyzed age-resolved transcriptomic data …
toward a molecular understanding of aging, we analyzed age-resolved transcriptomic data …
[HTML][HTML] Defining the age-dependent and tissue-specific circadian transcriptome in male mice
Cellular circadian clocks direct a daily transcriptional program that supports homeostasis
and resilience. Emerging evidence has demonstrated age-associated changes in circadian …
and resilience. Emerging evidence has demonstrated age-associated changes in circadian …