Most adult organs contain regenerative stem cells, often organized in specific niches. Stem
cell function is critical for tissue homeostasis and repair upon injury, and it is dependent on …

Adult stem cells are important for mammalian tissues, where they act as a cell reserve that
supports normal tissue turnover and can mount a regenerative response following acute …

Head and neck cancer is a malignant tumour with a high mortality rate characterized by late
diagnosis, high recurrence and metastasis rates, and poor prognosis. Head and neck …

Ubiquitylation is catalyzed by coordinated actions of E3 and E2 enzymes. Molecular
principles governing many important E3-E2 partnerships remain unknown, including those …

Mammalian target of rapamycin (mTOR) senses changes in nutrient status and stimulates
the autophagic process to recycle amino acids. However, the impact of nutrient stress on …

The development of haematopoietic stem cells into mature erythrocytes–erythropoiesis–is a
controlled process characterized by cellular reorganization and drastic reshaping of the …

Abstract The eukaryotic Glucose Induced Degradation/C-Terminal to LisH (GID/CTLH)
complex is a highly conserved E3 ubiquitin ligase involved in a broad range of biological …

Hematopoietic stem cells (HSCs) are vital for the differentiation of all mature blood cells, with
their homeostasis being tightly regulated by intrinsic and extrinsic factors. Alternative …

Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease characterized by
the progressive degeneration of motor neurons, leading to muscle atrophy, paralysis and …

Autophagy is a highly conserved cellular degradation process that regulates cellular
metabolism and homeostasis under normal and pathophysiological conditions. Autophagy …