MicroRNA-21 is a versatile regulator and potential treatment target in central nervous system disorders

X Bai, Z Bian - Frontiers in molecular neuroscience, 2022 - frontiersin.org
MicroRNAs (miRNAs) are a class of endogenous, non-coding, single-stranded RNAs with a
length of approximately 22 nucleotides that are found in eukaryotes. miRNAs are involved in …

Iron metabolism and ferroptosis in epilepsy

S Chen, Y Chen, Y Zhang, X Kuang, Y Liu… - Frontiers in …, 2020 - frontiersin.org
Epilepsy is a disease characterized by recurrent, episodic, and transient central nervous
system (CNS) dysfunction resulting from an excessive synchronous discharge of brain …

[HTML][HTML] Antioxidant activity of mesenchymal stem cell-derived extracellular vesicles restores hippocampal neurons following seizure damage

Q Luo, P Xian, T Wang, S Wu, T Sun, W Wang… - Theranostics, 2021 - ncbi.nlm.nih.gov
Oxidative stress is a critical event in neuronal damage following seizures. Mesenchymal
stem cell-derived extracellular vesicles (MSC-EVs) have been shown to be promising …

Dehydroepiandrosterone activates the GPER-mediated AMPK signaling pathway to alleviate the oxidative stress and inflammatory response in laying hens fed with …

Y Yao, H Wang, Y Yang, Z Jiang, H Ma - Life sciences, 2022 - Elsevier
Fatty liver hemorrhagic syndrome (FLHS) seriously threatens the layer industry due to it can
cause a sudden decline in egg production and acute death, and dietary supplement with …

Research progress on oxidative stress regulating different types of neuronal death caused by epileptic seizures

H Sun, X Li, Q Guo, S Liu - Neurological Sciences, 2022 - Springer
Clinical and experimental data hints that prolonged and repeated epileptic seizures can
lead to molecular, biochemical, metabolic, and structural changes in the brain, a continuous …

[HTML][HTML] Disorders of the central nervous system: Insights from Notch and Nrf2 signaling

Y Chen, J Pang, L Ye, Z Zhang, S Lin, N Lin… - Biomedicine & …, 2023 - Elsevier
The functional complexity of the central nervous system (CNS) is unparalleled in living
organisms. It arises from neural crest-derived cells that migrate by the exact route, leading to …

The increase of Nrf2 m6A modification induced by FTO downregulation promotes hippocampal neuron injury and aggravates the progression of epilepsy in a rat …

MQ Tian, J Li, XM Shu, CH Lang, J Chen, LY Peng… - Synapse, 2023 - Wiley Online Library
Epilepsy is a common chronic neurological disorder characterized by widespread neuronal
death. The purpose of this study was to investigate the role of nuclear factor erythroid 2 …

[PDF][PDF] Research progress on ferroptosis and its role in epilepsy.

X Liu, J Chen - Journal of Physiology & Pharmacology, 2022 - jpp.krakow.pl
Epilepsy is a disease characterized by central nervous system dysfunction induced by an
excessive synchronous discharge of cerebral neurons, with diverse etiologies and …

Impact of NQO1 dysregulation in CNS disorders

L Yuhan, M Khaleghi Ghadiri, A Gorji - Journal of Translational Medicine, 2024 - Springer
Abstract NAD (P) H Quinone Dehydrogenase 1 (NQO1) plays a pivotal role in the regulation
of neuronal function and synaptic plasticity, cellular adaptation to oxidative stress …

Regulatory basis of adipokines leptin and adiponectin in epilepsy: from signaling pathways to glucose metabolism

Y Shan, Y Chen, H Gu, Y Wang, Y Sun - Neurochemical Research, 2023 - Springer
Epilepsy is a common and severe neurological disorder in which impaired glucose
metabolism leads to changes in neuronal excitability that slow or promote the development …