Severe spinal cord injury causes permanent loss of function and sensation throughout the
body. The trauma causes a multifaceted torrent of pathophysiological processes which …

Highlights•Convergence between axon regeneration ability and abnormal synaptic structure
and function.•Axon regeneration, neuronal circuit assembly and recovery of functions in the …

It has been proposed that the local segregation of kinases and the tyrosine phosphatase
CD45 underpins T cell antigen receptor (TCR) triggering, but how such segregation occurs …

The generation of precise synaptic connections between developing neurons is critical to
the formation of functional neural circuits. Astrocyte-secreted glypican 4 induces formation of …

CD22 maintains a baseline level of B-cell inhibition to keep humoral immunity in check. As a
B-cell-restricted antigen, CD22 is targeted in therapies against dysregulated B cells that …

Glial-cell line derived neurotrophic factor (GDNF) bound to its co-receptor GFRα1 stimulates
the RET receptor tyrosine kinase, promoting neuronal survival and neuroprotection. The …

Proteoglycans (PGs) are a diverse family of proteins that consist of one or more
glycosaminoglycan (GAG) chains, covalently linked to a core protein. PGs are major …

Autism spectrum disorder (ASD) comprises a range of neurological conditions that affect
individuals' ability to communicate and interact with others. People with ASD often exhibit …

Trans-synaptic cell-adhesion molecules are critical for governing various stages of synapse
development and specifying neural circuit properties via the formation of multifarious …

Traumatic spinal cord injury produces long-term neurological damage, and presents a
significant public health problem with nearly 18,000 new cases per year in the US The injury …