Human antigen binding proteins that bind β-Klotho, FGF receptors and complexes thereof

SFS Hu, I Foltz, CT King, Y Li, T Arora - US Patent 9,284,378, 2016 - Google Patents
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Chimeric polypeptides and uses thereof

Y Li, X Wu, Z Wang - US Patent 8,324,160, 2012 - Google Patents
The disclosure provides nucleic acid molecules encoding chimeric polypeptides, chimeric
polypeptides, pharmaceuti cal compositions comprising chimeric polypeptides, and methods …

FGF21 polypeptides comprising two or more mutations and uses thereof

EJ Belouski, MM Ellison, AE Hamburger… - US Patent …, 2014 - Google Patents
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FGF-21 mutants comprising polyethylene glycol and uses thereof

KW Walker, CV Gegg, RI Hecht, EJ Belouski… - US Patent …, 2016 - Google Patents
(60) Provisional application No. 61/195,761, filed on Oct. Nature Genetics 26: 345-348. 10,
2008. Arner et ai.(2004)“FGF21 attenuates lipolysis in human adipocytes—A possible link to …

Binding proteins that bind to human FGFR1C, human β-klotho and both human FGFR1C and human β-klotho

R Smith, A Bakker, AN Duguay, P Li, Y Li - US Patent 8,372,952, 2013 - Google Patents
US8372952B2 - Binding proteins that bind to human FGFR1C, human β-klotho and both
human FGFR1C and human β-klotho - Google Patents US8372952B2 - Binding proteins that …

FGF 21 polypeptides comprising two or more mutations and uses thereof

EJ Belouski, MM Ellison, AE Hamburger… - US Patent …, 2014 - Google Patents
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FGF21 mutants comprising a mutation at position 98, 171 and/or 180

EJ Belouski, MM Ellison, AE Hamburger… - US Patent …, 2016 - Google Patents
2018-12-27 Assigned to AMGEN INC. reassignment AMGEN INC. ASSIGNMENT OF
ASSIGNORS INTEREST (SEE DOCUMENT FOR DETAILS). Assignors: LI, YUE-SHENG …

Human antigen binding proteins that bind β-klotho, FGF receptors and complexes thereof

SFS Hu, IN Foltz, CT King, Y Li, T Arora - US Patent 12,116,413, 2024 - Google Patents
US12116413B2 - Human antigen binding proteins that bind β-klotho, FGF receptors and
complexes thereof - Google Patents US12116413B2 - Human antigen binding proteins that …

Methods of treating non-alcoholic steatohepatitis using FGF21 mutants

EJ Belouski, MM Ellison, AE Hamburger… - US Patent …, 2023 - Google Patents
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Methods of treating non-alcoholic steatohepatitis using FGF21 mutants

EJ Belouski, MM Ellison, AE Hamburger… - US Patent …, 2021 - Google Patents
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