Advances in therapeutic targeting of cancer stem cells within the tumor microenvironment: an updated review
Despite great strides being achieved in improving cancer patients' outcomes through better
therapies and combinatorial treatment, several hurdles still remain due to therapy …
therapies and combinatorial treatment, several hurdles still remain due to therapy …
HIV latency in myeloid cells: challenges for a cure
A Chitrakar, M Sanz, SB Maggirwar, N Soriano-Sarabia - Pathogens, 2022 - mdpi.com
The use of antiretroviral therapy (ART) for Human Immunodeficiency Virus (HIV) treatment
has been highly successful in controlling plasma viremia to undetectable levels. However, a …
has been highly successful in controlling plasma viremia to undetectable levels. However, a …
[HTML][HTML] Development of humanized mouse and rat models with full-thickness human skin and autologous immune cells
The human skin is a significant barrier for protection against pathogen transmission. Rodent
models used to investigate human-specific pathogens that target the skin are generated by …
models used to investigate human-specific pathogens that target the skin are generated by …
Advances in humanized mouse models to improve understanding of HIV-1 pathogenesis and immune responses
A Gillgrass, JM Wessels, JX Yang… - Frontiers in …, 2021 - frontiersin.org
Although antiretroviral therapy has transformed human immunodeficiency virus-type 1 (HIV-
1) from a deadly infection into a chronic disease, it does not clear the viral reservoir, leaving …
1) from a deadly infection into a chronic disease, it does not clear the viral reservoir, leaving …
Progress in vocal fold regenerative biomaterials: an immunological perspective
Vocal folds are important to daily breathing, speech, and swallowing functions. Irreversible
changes to the vocal fold mucosa, such as scarring and atrophy, require regenerative …
changes to the vocal fold mucosa, such as scarring and atrophy, require regenerative …
Interests of the non-human primate models for HIV cure research
G Terrade, N Huot, C Petitdemange, M Lazzerini… - Vaccines, 2021 - mdpi.com
Non-human primate (NHP) models are important for vaccine development and also
contribute to HIV cure research. Although none of the animal models are perfect, NHPs …
contribute to HIV cure research. Although none of the animal models are perfect, NHPs …
Unleashing Digital Frontiers: Bridging Realities of Augmented Reality, Virtual Reality, and the Metaverse
This chapter adopts a historiographical methodology, meticulously retracing the lineage of
Augmented Reality (AR) from the 16th century and scrutinizing the conceptual genesis of …
Augmented Reality (AR) from the 16th century and scrutinizing the conceptual genesis of …
In situ analysis of neuronal injury and neuroinflammation during HIV-1 infection
Background Since the introduction of combination antiretroviral therapy (cART) the brain has
become an important human immunodeficiency virus (HIV) reservoir due to the relatively low …
become an important human immunodeficiency virus (HIV) reservoir due to the relatively low …
Nef defect attenuates HIV viremia and immune dysregulation in the bone marrow-liver-thymus-spleen (BLTS) humanized mouse model
In vitro studies have shown that deletion of nef and deleterious mutation in the Nef
dimerization interface attenuates HIV replication and associated pathogenesis. Humanized …
dimerization interface attenuates HIV replication and associated pathogenesis. Humanized …
Environmental Pollutants, Mucosal Barriers, and Pathogen Susceptibility; The Case for Aflatoxin B1 as a Risk Factor for HIV Transmission and Pathogenesis
EP Madeen, F Maldarelli, JD Groopman - Pathogens, 2021 - mdpi.com
HIV transmission risk is dependent on the infectivity of the HIV+ partner and personal
susceptibility risk factors of the HIV− partner. The mucosal barrier, as the internal gatekeeper …
susceptibility risk factors of the HIV− partner. The mucosal barrier, as the internal gatekeeper …