Currently, there is an incomplete understanding of the molecular pathogenesis of
meningiomas, the most common primary brain tumor. Several familial syndromes are …

DNA wraps around histone octamers to assemble nucleosomes, which pack into high-
ordered chromatin structure in the nucleus, and block access to the genetic material. The …

One-third of all primary central nervous system tumors in adults are meningiomas. Rarely,
meningiomas occur at multiple sites, usually occurring in individuals with type 2 …

Background The repressor element-1 silencing transcription factor/neuron-restrictive
silencer factor (REST/NRSF) is a master regulator of neuronal gene expression. REST …

SMARCC2 (BAF170) is one of the invariable core subunits of the ATP-dependent chromatin
remodeling BAF (BRG1-associated factor) complex and plays a crucial role in …

Mammalian spermiogenesis is of considerable biological interest especially due to the
unique chromatin remodeling events that take place during spermatid maturation. Here, we …

Melanomas resist conventional chemotherapeutics, in part, through intrinsic disrespect of
apoptotic checkpoint activation. In this study, using an unbiased genome-wide RNA …

Transcription factor 4 (TCF4 also known as ITF2 or E2-2) is a basic helix-loop-helix (bHLH)
protein associated with Pitt–Hopkins syndrome, intellectual disability, and schizophrenia …

To fully understand cell type identity and function in the nervous system there is a need to
understand neuronal gene expression at the level of isoform diversity. Here we applied Next …

Balanced mRNA isoform diversity and abundance are spatially and temporally regulated
throughout cellular differentiation. The proportion of expressed isoforms contributes to cell …