Intracellular delivery of biological agents such as peptides, proteins, and nucleic acids
generally rely on the endocytic pathway as the major uptake mechanism, resulting in their …

A dominant area of antibody research is the extension of the use of this mighty experimental
and therapeutic tool for the specific detection of molecules for diagnostics, visualization, and …

Cytosolic transport is an essential requirement but a major obstacle to efficient delivery of
therapeutic peptides, proteins and nucleic acids. Current understanding of cytosolic delivery …

Bioactive macromolecular peptides and oligonucleotides have significant therapeutic
potential. However, due to their size, they have no ability to enter the cytoplasm of cells …

Oncogenic Ras mutants, frequently detected in human cancers, are high-priority anticancer
drug targets. However, direct inhibition of oncogenic Ras mutants with small molecules has …

Protein-based therapeutics represent a rapidly growing segment of approved disease
treatments. Successful intracellular delivery of proteins is an important precondition for …

Immunotoxins (ITs) are attractive anticancer modalities aimed at cancer-specific delivery of
highly potent cytotoxic protein toxins. An IT consists of a targeting domain (an antibody …

Because of their favorable properties as macromolecular drugs, antibodies are a very
successful therapeutic modality for interfering with disease-relevant targets in the …

Polymer nanoparticles offer significant benefits for improving delivery of biological
therapeutics such as DNA and proteins, as they allow the cargo to be protected until it is …

Therapeutic antibodies targeting disease-associated antigens are key tools in the treatment
of cancer and autoimmunity. So far, therapeutic antibodies have targeted antigens that are …