[HTML][HTML] Cyanobacteria, Cyanotoxins, and Neurodegenerative Diseases: Dangerous Liaisons

P Sini, TBC Dang, M Fais, M Galioto… - International journal of …, 2021 - mdpi.com
The prevalence of neurodegenerative disease (ND) is increasing, partly owing to extensions
in lifespan, with a larger percentage of members living to an older age, but the ND aetiology …

Is exposure to BMAA a risk factor for neurodegenerative diseases? A response to a critical review of the BMAA hypothesis

D Ra, B Sa, B Sl, M Js, M Sj, D DA, S Ew, KO, B Eb… - Neurotoxicity …, 2021 - Springer
In a literature survey, Chernoff et al.(2017) dismissed the hypothesis that chronic exposure
to β-N-methylamino-L-alanine (BMAA) may be a risk factor for progressive …

Microbial BMAA elicits mitochondrial dysfunction, innate immunity activation, and Alzheimer's disease features in cortical neurons

DF Silva, E Candeias, AR Esteves… - Journal of …, 2020 - Springer
Background After decades of research recognizing it as a complex multifactorial disorder,
sporadic Alzheimer's disease (sAD) still has no known etiology. Adding to the myriad of …

Cellular and Molecular Aspects of the β-N-Methylamino-l-alanine (BMAA) Mode of Action within the Neurodegenerative Pathway: Facts and Controversy

N Delcourt, T Claudepierre, T Maignien, N Arnich… - Toxins, 2017 - mdpi.com
The implication of the cyanotoxin β-N-methylamino-l-alanine (BMAA) in long-lasting
neurodegenerative disorders is still a matter of controversy. It has been alleged that chronic …

Iron and other metals in the pathogenesis of Parkinson's disease: Toxic effects and possible detoxification

G Bjørklund, T Hofer, VM Nurchi, J Aaseth - Journal of inorganic …, 2019 - Elsevier
Of the documented cases of Parkinson's disease (PD), about 10% have a genetic
background. The remaining cases of PD have unknown etiology. Thus, environmental …

[HTML][HTML] Food web biomagnification of the neurotoxin β-N-methylamino-L-alanine in a diatom-dominated marine ecosystem in China

C Wang, C Yan, J Qiu, C Liu, Y Yan, Y Ji… - Journal of Hazardous …, 2021 - Elsevier
The neurotoxin β-N-methylamino-L-alanine (BMAA) reported in some cyanobacteria and
eukaryote microalgae is a cause of concern due to its potential risk of human …

BMAA-protein interactions: A possible new mechanism of toxicity

R Van Onselen, TG Downing - Toxicon, 2018 - Elsevier
Abstract β-N-methylamino-L-alanine (BMAA) has been shown to accumulate in organisms
by associating with host proteins. It has been proposed that this association is the result of …

Neurotoxin BMAA and its isomeric amino acids in cyanobacteria and cyanobacteria-based food supplements

K Manolidi, TM Triantis, T Kaloudis, A Hiskia - Journal of hazardous …, 2019 - Elsevier
Cyanobacteria are photosynthetic microorganisms distributed globally in aquatic and
terrestrial environments. They are also industrially cultivated to be used as dietary …

Environmental bacteria as triggers to brain disease: Possible mechanisms of toxicity and associated human risk

A Courtier, D Potheret, P Giannoni - Life Sciences, 2022 - Elsevier
Aims Brain disease, in its many forms, has recently demonstrated a great socio-economic
impact and represents one of the hardest challenges of present research. Although each …

The Effects of Long-term, Low-dose β-N-methylamino-l-alanine (BMAA) Exposures in Adult SODG93R Transgenic Zebrafish

RD Weeks, SA Banack, S Howell, P Thunga… - Neurotoxicity …, 2023 - Springer
Abstract β-N-Methylamino-l-alanine (BMAA) is a non-proteinogenic amino acid produced by
cyanobacteria, which has been implicated in several neurodegenerative diseases, including …