The neurovascular unit (NVU) is a dynamic center for substance exchange between the
blood and the brain, making it an essential gatekeeper for central nervous system (CNS) …

The blood–brain barrier (BBB) is a unique and selective feature of the central nervous
system's vasculature. BBB dysfunction has been observed as an early sign of Alzheimer's …

Deterioration of brain capillary flow and architecture is a hallmark of aging and dementia. It
remains unclear how loss of brain pericytes in these conditions contributes to capillary …

Evidence suggests a unique association between bone aging and neurodegenerative/
cerebrovascular disorders. However, the mechanisms underlying bone‐brain interplay …

Since 1906, when Dr. Alois Alzheimer first described in a patient “a peculiar severe disease
process of the cerebral cortex”, people suffering from this pathology have been waiting for a …

Cognitive impairment associated with vascular etiology has been of considerable interest in
the development of dementia. Recent studies have started to uncover cerebral blood flow …

Aims We sought to identify and optimise a universally available histological marker for
pericytes in the human brain. Such a marker could be a useful tool for researchers. Further …

Alzheimer's disease (AD) is a devastating neurodegenerative disorder that leads to
progressive cognitive decline and neuropathological changes. Pericytes, which are vessel …

Platelet-derived growth factors are critical for cerebrovascular development and
homeostasis. Abnormalities in this signalling pathway are implicated in neurological …

Degenerative cervical myelopathy (DCM) is the most prevalent cause of spinal cord
dysfunction in the aging population. Significant neurological deficits may result from a …