MS imaging of multicellular tumor spheroids and organoids as an emerging tool for personalized medicine and drug discovery

Y Wang, AB Hummon - Journal of Biological Chemistry, 2021 - ASBMB
MS imaging (MSI) is a powerful tool in drug discovery because of its ability to interrogate a
wide range of endogenous and exogenous molecules in a broad variety of samples. The …

A versatile deep learning architecture for classification and label-free prediction of hyperspectral images

B Manifold, S Men, R Hu, D Fu - Nature machine intelligence, 2021 - nature.com
Hyperspectral imaging is a technique that provides rich chemical or compositional
information not regularly available to traditional imaging modalities such as intensity …

MALDI-MSI analysis of cancer drugs: Significance, advances, and applications

Q He, C Sun, J Liu, Y Pan - TrAC Trends in Analytical Chemistry, 2021 - Elsevier
Because of the heterogeneity and complexity of tumor structure, cancer drugs often cannot
effectively reach the tumor, which is one of the reasons for drug resistance and treatment …

Considerations for MALDI-based quantitative mass spectrometry imaging studies

F Tobias, AB Hummon - Journal of proteome research, 2020 - ACS Publications
Significant advances in mass spectrometry imaging (MSI) have pushed the boundaries in
obtaining spatial information and quantification in biological samples. Quantitative MSI …

Quantification of Irinotecan in Single Spheroids Using Internal Standards by MALDI Mass Spectrometry Imaging

Y Wang, AB Hummon - Analytical Chemistry, 2023 - ACS Publications
Matrix-assisted laser desorption/ionization mass spectrometry imaging (MALDI-MSI) has
been used to visualize molecular distributions in various biological samples. While it has …

Metabolic perturbation score-based mass spectrometry imaging spatially resolves a functional metabolic response

X Song, Q Zang, J Zhang, S Gao, K Zheng… - Analytical …, 2023 - ACS Publications
Metabolic perturbation score-based mass spectrometry imaging (MPS-MSI) is proposed to
reveal the spatially resolved functional metabolic response associated with disease …

Microfluidics in High-Throughput Drug Screening: Organ-on-a-Chip and C. elegans-Based Innovations

S Yoon, D Kilicarslan You, U Jeong, M Lee, E Kim… - Biosensors, 2024 - mdpi.com
The development of therapeutic interventions for diseases necessitates a crucial step known
as drug screening, wherein potential substances with medicinal properties are rigorously …

[HTML][HTML] Promise of spatially resolved omics for tumor research

Y Zhou, X Jiang, X Wang, J Huang, T Li, H Jin… - Journal of …, 2023 - Elsevier
Tumors are spatially heterogeneous tissues that comprise numerous cell types with intricate
structures. By interacting with the microenvironment, tumor cells undergo dynamic changes …

Simultaneous and sensitive detection of multiple small biological molecules by microfluidic paper-based analytical device integrated with zinc oxide nanorods

LX Feng, C Tang, XX Han, HC Zhang, FN Guo, T Yang… - Talanta, 2021 - Elsevier
In this work, ZnO nanorods (ZnO NRs) with different sizes were hydrothermally grown on the
surface of Whatman filter paper for the fabrication of a microfluidic paper-based device …

Continuous flow delivery system for the perfusion of scaffold-based 3D cultures

ZR Sitte, EE Karlsson, H Li, H Zhou, MR Lockett - Lab on a Chip, 2024 - pubs.rsc.org
The paper-based culture platform developed by Whitesides readily incorporates tissue-like
structures into laboratories with established workflows that rely on monolayer cultures. Cell …