Cell-based therapies are being developed for various neurodegenerative diseases that
affect the central nervous system (CNS). Concomitantly, the roles of individual cell types in …

Abstract Alcohol Use Disorder is a complex genetic disorder, involving genetic, neural, and
environmental factors, and their interactions. The Collaborative Study on the Genetics of …

Multiple sclerosis (MS) is the most common chronic central nervous system inflammatory
disease. Individual courses are highly variable, with complete remission in some patients …

Ascl1 and Ngn2, closely related proneural transcription factors, are able to convert mouse
embryonic stem cells into induced neurons. Despite their similarities, these factors elicit only …

Axonal transport is essential for neuronal survival. This is driven by microtubule motors
including dynein, which transports cargo from the axon tip back to the cell body. This …

High-risk preterm infants are affected by a higher incidence of cognitive developmental
deficits due to the unavoidable risk factor of oxygen toxicity. Caffeine is known to have a …

MUNC18-1 is an essential protein of the regulated secretion machinery. De novo,
heterozygous mutations in STXBP1, the human gene encoding this protein, lead to a severe …

Astrocytes are essential for the formation and maintenance of neural networks. However, a
major technical challenge for investigating astrocyte function and disease-related …

NGN2-driven induced pluripotent stem cell (iPSC)-to-neuron conversion is a popular
method for human neurological disease modeling. In this study, we present a standardized …

Synaptojanin-1 (SJ1) is a major neuronal-enriched PI (4, 5) P2 4-and 5-phosphatase
implicated in the shedding of endocytic factors during endocytosis. A mutation (R258Q) that …