Exercise elicits coordinated multi-organ responses including skeletal muscle, vasculature,
heart, and lung. In the short term, the output of the heart increases to meet the demand of …

Exercise can prevent and improve the pathophysiology of diseases and promote healthy
aging. Thus, understanding the mechanisms that regulate the beneficial effects of exercise …

Aging is a progressive and irreversible pathophysiological process that manifests as the
decline in tissue and cellular functions, along with a significant increase in the risk of various …

Disuse and aging are known risk factors associated with low bone mass and quality
deterioration, resulting in increased fracture risk. Indeed, current and emerging evidence …

Physical activity is associated with beneficial adaptations in human and rodent metabolism.
We studied over 50 complex traits before and after exercise intervention in middle-aged men …

Preclinical studies have demonstrated exercise improves various types of behaviours such
as anxiety-like, depression-like, and cognition-like behaviours. However, these findings …

Background During aging, there is a physiological decline, an increase of morbidity and
mortality, and a natural change in the gut microbiome. In this study, we investigated the …

Aging is a major risk factor for cognitive impairment. Aerobic exercise benefits brain function
and may promote cognitive health in older adults. However, underlying biological …

Artificial light is transforming the nighttime environment and quickly becoming one of the
most pervasive pollutants on earth. Across taxa, light entrains endogenous circadian clocks …

Skeletal muscle is important for overall functionality and health. Ageing is associated with an
accumulation of damage to mitochondrial DNA and proteins. In particular, damage to …