Dopamine is a prototypical neuromodulator that controls circuit function through G protein-
coupled receptor signalling. Neuromodulators are volume transmitters, with release followed …

There is increasing interest among functional neurosurgeons in the potential for novel
therapies to impact upon diseases beyond movement disorders and pain. A target of …

Dopamine (DA) transmission is governed by processes that regulate release from axonal
boutons in the forebrain and the somatodendritic compartment in midbrain, and by …

Dopamine D2-autoreceptors play a key role in regulating the activity of dopamine neurons
and control the synthesis, release and uptake of dopamine. These G i/o-coupled inhibitory …

Dopamine is well recognized as a neurotransmitter in the brain, and regulates critical
functions in a variety of peripheral systems. Growing research has also shown that …

Schultz, Wolfram. Predictive reward signal of dopamine neurons. J. Neurophysiol. 80: 1–27,
1998. The effects of lesions, receptor blocking, electrical self-stimulation, and drugs of abuse …

The reason for the high frequency of depression and anxiety in Parkinson's disease is poorly
understood. Degeneration of neurotransmitter systems other than dopamine might play a …

The dopamine transporter (DAT) transports extracellular dopamine into the intracellular
space contributing to the regulation of dopamine neurotransmission. A reduction of DAT …

Highlights•Chronic exposure to aged PS-MPs caused more severe neurotoxicity than virgin
PS-MPs.•Damage to neurons systems following exposure to aged PS-MPs was …

The importance of the striatal dopamine (DA) deficiency and the DA substituting property of
levodopa for the pathophysiology and therapy of Parkinson's disease (PD) is reiterated. In …