The aim of this review is to analyse critically the recent literature on the clinical
pharmacokinetics and pharmacodynamics of tacrolimus in solid organ transplant recipients …

In 2007, a consortium of European experts on tacrolimus (TAC) met to discuss the most
recent advances in the drug/dose optimization of TAC taking into account specific clinical …

The calcineurin inhibitors (CNIs) tacrolimus and cyclosporine are widely used
immunosuppressive drugs characterized by high pharmacokinetic and pharmacodynamic …

WHAT IS ALREADY KNOWN ABOUT THIS SUBJECT• Patients with low tacrolimus troughs
are at a higher risk of rejection while those with high troughs are at an increased risk for …

Aims The aims of this study were to describe the pharmacokinetics of tacrolimus immediately
after kidney transplantation, and to develop a clinical tool for selecting the best starting dose …

Abstract Background and Objectives Numerous population pharmacokinetic (PK) models of
tacrolimus in adult transplant recipients have been published to characterize tacrolimus PK …

This review summarises the available data on the population pharmacokinetics of tacrolimus
and use of Maximum A Posteriori (MAP) Bayesian estimation to predict tacrolimus exposure …

What is already known about this subject• In spite of its success in ensuring graft survival,
therapeutic use of tacrolimus is complicated by its narrow therapeutic index and wide intra …

Background: Information on the pharmacokinetics of tacrolimus during pregnancy is limited
to case reports despite the increasing number of pregnant women being prescribed …

Titrating tacrolimus concentration in liver transplantation recipients remains a challenge in
the early post-transplant period. This multicenter retrospective cohort study aimed to develop …