Background: The incidence of dementia is projected to rise over the coming decades, but
with no sensitive diagnostic tests available. Vascular pathology precedes the deposition of …

Significance: The brain has high energetic requirements and is therefore highly dependent
on adequate cerebral blood supply. To compensate for dangerous fluctuations in cerebral …

Strokes often cause multiple behavioural deficits that are correlated at the population level.
Here, we show that motor and attention deficits are selectively associated with abnormal …

Stroke disrupts the brain's vascular supply, not only within but also outside areas of
infarction. We investigated temporal delays (lag) in resting state functional magnetic …

Neurovascular coupling, the close spatial and temporal relationship between neural activity
and hemodynamics, is disrupted in pathological brain states. To understand the altered …

We aimed to assess cerebral autoregulation (CA) and neurovascular coupling (NVC) in
stroke patients of differing severity comparing responses to healthy controls and explore the …

Cardiopulmonary bypass surgery is associated with a high incidence of neurological
complications, including stroke, delirium and cognitive impairment. The development of …

Background: Acute stroke is known to impair cerebral blood flow (CBF) regulation, but the
longitudinal changes of these effects have been poorly reported. The main CBF regulatory …

Cerebral blood flow (CBF) regulation can be impaired in acute ischemic stroke but the
combined effects of dynamic cerebral autoregulation (CA), CO2 cerebrovascular reactivity …

Given the complexity of cerebral pathology in patients with acute brain injury, various
neuromonitoring strategies have been developed to better appreciate physiologic …