The Caco-2 cellular monolayer is a widely accepted in vitro model to predict human
permeability but suffering from several and critical limitations. Therefore, some alternative …

New organometallic gold (III) and platinum (II) complexes containing iminophosphorane
ligands are described. Most of them are more cytotoxic to a number of human cancer cell …

Hydrogels are widely studied as drug delivery system. In this work we propose the
employment of tetrakis (hydroxymethyl) phosphonium chloride as crosslinking agent to …

Our aim is to develop and to validate the in situ closed loop perfusion method in rat colon
and to compare with small intestine and Caco-2 cell models. Correlations with human oral …

The BBB is a protective entity that prevents external substances from reaching the CNS but it
also hinders the delivery of drugs into the brain when they are needed. The main objective …

The purpose of this investigation was to develop an exploratory two-step level A IVIVC for
three telmisartan oral immediate release formulations, the reference product Micardis, and …

Introduction In vitro models with high predictive ability have been revealed as strong tools for
pharmaceutical industry. However, the variability in permeability estimations complicates the …

Progesterone (PG) affords neuroprotection in degenerative diseases associated to oxidative
stress, such as cataracts, age-related macular degeneration, glaucoma, diabetic retinopathy …

A major parameter controlling the extent and rate of oral drug absorption is permeability
through the lipid bilayer of intestinal epithelial cells. Here, a biomimetic artificial membrane …

This chapter discusses the role of cell-and tissue-based in vitro models for drug permeability
during the early stages of drug development. A general description of different experimental …