DNA double-strand breaks (DSBs) are the most lethal DNA damages which lead to severe
genome instability. Phosphorylation is one of the most important protein post-translation …

Ataxia telangiectasia, one of the rare human autosomal recessive disorders, results from a
mutation in the Ataxia telangiectasia mutated kinase (ATM) gene, leading to high …

Gastric cancer (GC) is a major health concern worldwide, presenting a complex
pathophysiology that has hindered many therapeutic efforts so far. In this context, purinergic …

ATM is an apical kinase of the DNA damage response involved in the repair of DNA double-
strand breaks. Germline ATM variants (gATM) have been associated with an increased risk …

The protein kinase ataxia telangiectasia mutated (ATM) is a constituent of the
phosphatidylinositol 3-kinase-related kinase (PIKK) family, exerting a pivotal influence on …

Hepatocellular carcinoma is currently the most common malignancy of the liver. It typically
occurs due to a series of oncogenic mutations that lead to aberrant cell replication. Most …

Simple Summary Gastric cancer (GC) is a highly aggressive malignancy affecting the
digestive system and characterized by notable variations in its nature. Although survival …

Simple Summary The current routine treatment for glioblastoma (GB), the most lethal high-
grade brain tumor in adults, aims to induce DNA damage in the tumor. However, the tumor …

Cellular aging has drawn the attention of researchers, scientists, and biotech businesses for
the treatment of a number of medical conditions. Cellular aging is primarily defined by …

Cancer is a life-threatening disease. Its treatment is challenging due to the disease's
heterogenous nature, and there is no universal therapy. In the last decades, different …