Mouse models of sarcopenia: classification and evaluation

W Xie, M He, D Yu, Y Wu, X Wang, S Lv… - Journal of cachexia …, 2021 - Wiley Online Library
Sarcopenia is a progressive and widespread skeletal muscle disease that is related to an
increased possibility of adverse consequences such as falls, fractures, physical disabilities …

Role of antioxidant enzymes and small molecular weight antioxidants in the pathogenesis of age-related macular degeneration (AMD)

P Tokarz, K Kaarniranta, J Blasiak - Biogerontology, 2013 - Springer
Cells in aerobic condition are constantly exposed to reactive oxygen species (ROS), which
may induce damage to biomolecules, including proteins, nucleic acids and lipids. In normal …

Combination of Coenzyme Q10 Intake and Moderate Physical Activity Counteracts Mitochondrial Dysfunctions in a SAMP8 Mouse Model

C Andreani, C Bartolacci, M Guescini… - Oxidative Medicine …, 2018 - Wiley Online Library
Aging skeletal muscles are characterized by a progressive decline in muscle mass and
muscular strength. Such muscular dysfunctions are usually associated with structural and …

Pathogenesis of presbycusis in animal models: a review

AR Fetoni, PM Picciotti, G Paludetti, D Troiani - Experimental gerontology, 2011 - Elsevier
Presbycusis is the most common cause of hearing loss in aged subjects, reducing
individual's communicative skills. Age related hearing loss can be defined as a progressive …

Cellular senescence: mechanisms, morphology, and mouse models

J Beck, I Horikawa, C Harris - Veterinary pathology, 2020 - journals.sagepub.com
Cellular senescence is a cell cycle arrest in damaged or aged cells. Although this represents
a critical mechanism of tumor suppression, persistence of senescent cells during aging …

A diet rich in olive oil phenolics reduces oxidative stress in the heart of SAMP8 mice by induction of Nrf2-dependent gene expression

B Bayram, B Ozcelik, S Grimm, T Roeder… - Rejuvenation …, 2012 - liebertpub.com
A Mediterranean diet rich in olive oil has been associated with health benefits in humans. It
is unclear if and to what extent olive oil phenolics may mediate these health benefits. In this …

Ubiquinol-10 supplementation activates mitochondria functions to decelerate senescence in senescence-accelerated mice

G Tian, J Sawashita, H Kubo, S Nishio… - Antioxidants & redox …, 2014 - liebertpub.com
Aim: The present study was conducted to define the relationship between the anti-aging
effect of ubiquinol-10 supplementation and mitochondrial activation in senescence …

The behavioral, pathological and therapeutic features of the senescence-accelerated mouse prone 8 strain as an Alzheimer's disease animal model

X Cheng, W Zhou, Y Zhang - Ageing Research Reviews, 2014 - Elsevier
Alzheimer's disease (AD) is a widespread and devastating progressive neurodegenerative
disease. Disease-modifying treatments remain beyond reach, and the etiology of the …

Muscle mass, structural and functional investigations of senescence-accelerated mouse P8 (SAMP8)

GA Yun, KS Leung, PMF Siu, JH Qin… - Experimental …, 2015 - jstage.jst.go.jp
Sarcopenia is an age-related systemic syndrome with progressive deterioration in skeletal
muscle functions and loss in mass. Although the senescence-accelerated mouse P8 …

Dietary fructooligosaccharide and glucomannan alter gut microbiota and improve bone metabolism in senescence-accelerated mouse

K Tanabe, S Nakamura… - Journal of agricultural …, 2019 - ACS Publications
Gut microbiota improved using prebiotics may delay the onset of senescence-related health
problems. We hypothesized that prolonged intake of prebiotics delays senile osteoporosis …