Exosomes─ nature's lipid nanoparticles, a rising star in drug delivery and diagnostics

R Tenchov, JM Sasso, X Wang, WS Liaw, CA Chen… - ACS …, 2022 - ACS Publications
Exosomes are a subgroup of nanosized extracellular vesicles enclosed by a lipid bilayer
membrane and secreted by most eukaryotic cells. They represent a route of intercellular …

The role of lipids in exosome biology and intercellular communication: Function, analytics and applications

J Donoso‐Quezada, S Ayala‐Mar, J González‐Valdez - Traffic, 2021 - Wiley Online Library
Exosomes are extracellular vesicles that in recent years have received special attention for
their regulatory functions in numerous biological processes. Recent evidence suggests a …

Current knowledge on exosome biogenesis and release

NP Hessvik, A Llorente - Cellular and Molecular Life Sciences, 2018 - Springer
Exosomes are nanosized membrane vesicles released by fusion of an organelle of the
endocytic pathway, the multivesicular body, with the plasma membrane. This process was …

Lysosomal exocytosis, exosome release and secretory autophagy: the autophagic-and endo-lysosomal systems go extracellular

S Buratta, B Tancini, K Sagini, F Delo… - International journal of …, 2020 - mdpi.com
Beyond the consolidated role in degrading and recycling cellular waste, the autophagic-and
endo-lysosomal systems play a crucial role in extracellular release pathways. Lysosomal …

Introduction to extracellular vesicles: biogenesis, RNA cargo selection, content, release, and uptake

ER Abels, XO Breakefield - Cellular and molecular neurobiology, 2016 - Springer
Extracellular vesicles are a heterogeneous group of membrane-limited vesicles loaded with
various proteins, lipids, and nucleic acids. Release of extracellular vesicles from its cell of …

Exosomes: from garbage bins to promising therapeutic targets

M H. Rashed, E Bayraktar, G K. Helal… - International journal of …, 2017 - mdpi.com
Intercellular communication via cell-released vesicles is a very important process for both
normal and tumor cells. Cell communication may involve exosomes, small vesicles of …

Mesenchymal stem cell-derived extracellular vesicles: toward cell-free therapeutic applications

S Rani, AE Ryan, MD Griffin, T Ritter - Molecular Therapy, 2015 - cell.com
Mesenchymal stem (stromal) cells (MSCs) are multipotent cells with the ability to differentiate
into several cell types, thus serving as a cell reservoir for regenerative medicine. Much of the …

Exosomes as mediators of immune regulation and immunotherapy in cancer

FG Kugeratski, R Kalluri - The FEBS Journal, 2021 - Wiley Online Library
Exosomes are nanosized extracellular vesicles of endosomal origin that enclose a multitude
of functional biomolecules. Exosomes have emerged as key players of intercellular …

Biological properties of extracellular vesicles and their physiological functions

M Yáñez-Mó, PRM Siljander, Z Andreu… - Journal of …, 2015 - Taylor & Francis
In the past decade, extracellular vesicles (EVs) have been recognized as potent vehicles of
intercellular communication, both in prokaryotes and eukaryotes. This is due to their capacity …

Biogenesis, secretion, and intercellular interactions of exosomes and other extracellular vesicles

M Colombo, G Raposo, C Théry - Annual review of cell and …, 2014 - annualreviews.org
In the 1980s, exosomes were described as vesicles of endosomal origin secreted from
reticulocytes. Interest increased around these extracellular vesicles, as they appeared to …