Actin-associated proteins (AAPs) act on monomeric globular actin (G-actin) and polymerized
filamentous actin (F-actin) to regulate their dynamics and architectures which ultimately …

Spectrins are cytoskeletal proteins that are expressed ubiquitously in the mammalian
nervous system. Pathogenic variants in SPTAN1, SPTBN1, SPTBN2 and SPTBN4, four of …

SPTBN1 encodes βII-spectrin, the ubiquitously expressed β-spectrin that forms micrometer-
scale networks associated with plasma membranes. Mice deficient in neuronal βII-spectrin …

The actin cytoskeleton mediates mechanical coupling between cells and their tissue
microenvironments. The architecture and composition of actin networks are modulated by …

The spectrin-based membrane skeleton is a ubiquitous membrane-associated two-
dimensional cytoskeleton underneath the lipid membrane of metazoan cells. Mutations of …

The calponin homology (CH) domain is one of the most common modules in various actin-
binding proteins and is characterized by an α-helical fold. The CH domain plays important …

Actin-cross-linking proteins assemble actin filaments into higher-order structures essential
for orchestrating cell shape, adhesion, and motility. Missense mutations in the tandem …

RtcB enzymes are RNA ligases that play essential roles in tRNA splicing, unfolded protein
response, and RNA repair. In metazoa, RtcB functions as part of a five-subunit tRNA ligase …

To orchestrate cell mechanics, trafficking, and motility, cytoskeletal filaments must assemble
into higher-order networks whose local subcellular architecture and composition specify …

The assembly of actin filaments into distinct cytoskeletal structures plays a critical role in cell
physiology, but how proteins localize differentially to these structures within a shared …