Pooled Genome-Scale CRISPR Screens in Single Cells

D Schraivogel, LM Steinmetz… - Annual Review of …, 2023 - annualreviews.org
Assigning functions to genes and learning how to control their expression are part of the
foundation of cell biology and therapeutic development. An efficient and unbiased method to …

Preclinical Anticipation of On-and Off-Target Resistance Mechanisms to Anti-Cancer Drugs: A Systematic Review

PJ Dziubańska-Kusibab, E Nevedomskaya… - International Journal of …, 2024 - mdpi.com
The advent of targeted therapies has led to tremendous improvements in treatment options
and their outcomes in the field of oncology. Yet, many cancers outsmart precision drugs by …

[HTML][HTML] No country for old methods: New tools for studying microproteins

F Valdivia-Francia, A Sendoel - Iscience, 2024 - ncbi.nlm.nih.gov
Microproteins encoded by small open reading frames (sORFs) have emerged as a
fascinating frontier in genomics. Traditionally overlooked due to their small size, recent …