Progresses of T-cell-engaging bispecific antibodies in treatment of solid tumors
J Liu, J Zhu - International Immunopharmacology, 2024 - Elsevier
T-cell-engaging bispecific antibody (TCB) therapies have emerged as a promising
immunotherapeutic approach, effectively redirecting effector T cells to selectively eliminate …
immunotherapeutic approach, effectively redirecting effector T cells to selectively eliminate …
Population-based targeted sequencing of 54 candidate genes identifies PALB2 as a susceptibility gene for high-grade serous ovarian cancer
H Song, EM Dicks, J Tyrer, M Intermaggio… - Journal of medical …, 2021 - jmg.bmj.com
Purpose The known epithelial ovarian cancer (EOC) susceptibility genes account for less
than 50% of the heritable risk of ovarian cancer suggesting that other susceptibility genes …
than 50% of the heritable risk of ovarian cancer suggesting that other susceptibility genes …
Polygenic risk impacts PDGFRA mutation penetrance in non-syndromic cleft lip and palate
Non-syndromic cleft lip with or without cleft palate (NSCL/P) is a common, severe
craniofacial malformation that imposes significant medical, psychosocial and financial …
craniofacial malformation that imposes significant medical, psychosocial and financial …
[HTML][HTML] Ultrarare Missense Variants Implicated in Utah Pedigrees Multiply Affected With Schizophrenia
Background Recent work from the Schizophrenia Exome Sequencing Meta-analysis
(SCHEMA) consortium showed significant enrichment of ultrarare variants in schizophrenia …
(SCHEMA) consortium showed significant enrichment of ultrarare variants in schizophrenia …
[HTML][HTML] Integrated case-control and somatic-germline interaction analyses of melanoma susceptibility genes
While a number of genes have been implicated in melanoma susceptibility, the role of
protein-coding variation in melanoma development and progression remains …
protein-coding variation in melanoma development and progression remains …
An evaluation of genetic predisposition to congenital anomalies and pediatric cancer supports KAT6B as a novel neuroblastoma susceptibility gene
Purpose Although congenital anomalies are among the strongest risk factors for developing
pediatric cancer, the genetic underpinnings remain unclear. Therefore, we evaluated …
pediatric cancer, the genetic underpinnings remain unclear. Therefore, we evaluated …
Integrated case-control and somatic-germline interaction analyses of soft-tissue sarcoma
Purpose The contribution of rare genetic variation in the development of soft-tissue sarcoma
(STS) remains underexplored. To address this gap, we conducted a whole-exome case …
(STS) remains underexplored. To address this gap, we conducted a whole-exome case …
Rare Variant Association Studies In Crohn'S Disease And Colorectal Cancer: Methods And Applications
JS Chen - 2021 - digitalcommons.library.tmc.edu
Genetic factors account for a substantial portion of Crohn's disease and colorectal cancer
(CRC) risk. Patients with Crohn's disease, a condition that causes chronic inflammation of …
(CRC) risk. Patients with Crohn's disease, a condition that causes chronic inflammation of …
A whole-exome case-control association study to characterize the contribution of rare coding variation to pancreatic cancer risk
Pancreatic cancer is a deadly disease that accounts for approximately 5% of cancer deaths
worldwide, with a dismal 5-year survival rate of 10%. Known genetic risk factors explain only …
worldwide, with a dismal 5-year survival rate of 10%. Known genetic risk factors explain only …