Despite the recent advances in controlling some viral pathogens, most viral infections still
lack specific treatment. Indeed, the need for effective therapeutic strategies to combat 'old' …

The clinical, social, and economic impacts of the coronavirus disease 2019 (COVID-19)
pandemic, originated by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) …

Remdesivir (GS-5734) is a 1′-cyano-substituted adenosine nucleotide analogue prodrug
that shows broad-spectrum antiviral activity against several RNA viruses. This compound is …

Antiviral therapies that impede virus entry are attractive because they act on the first phase
of the infectious cycle. Drugs that target pathways common to multiple viruses are …

Background Remdesivir has received significant attention for its potential application in the
treatment of COVID-19, caused by SARS-CoV-2. Remdesivir has already been tested for …

Abstract Since coronavirus disease 2019 (COVID-19) started as a fast-spreading pandemic,
causing a huge number of deaths worldwide, several therapeutic options have been tested …

In the last years the rapid development of Nucleic Acid Based Drugs (NABDs) to be used in
gene therapy has had a great impact in the medical field, holding enormous promise …

Ebola Virus Disease (EVD) is one of the most lethal transmissible infections, characterized
by a high fatality rate, and caused by a member of the Filoviridae family. The recent large …

Ebola virus (EBOV), a member of the family Filoviridae, is responsible for causing Ebola
virus disease (EVD)(formerly named Ebola hemorrhagic fever). This is a severe, often fatal …

Macrolides are a large group of antibiotics characterised by the presence of a macro-lactone
ring of variable size. The prototype of macrolide antibiotics, erythromycin was first produced …