Angiotensin-converting enzyme 2: SARS-CoV-2 receptor and regulator of the renin-angiotensin system: celebrating the 20th anniversary of the discovery of ACE2

M Gheblawi, K Wang, A Viveiros, Q Nguyen… - Circulation …, 2020 - Am Heart Assoc
ACE2 (angiotensin-converting enzyme 2) has a multiplicity of physiological roles that
revolve around its trivalent function: a negative regulator of the renin-angiotensin system …

Role of oxidative stress on SARS-CoV (SARS) and SARS-CoV-2 (COVID-19) infection: a review

S Suhail, J Zajac, C Fossum, H Lowater… - The protein journal, 2020 - Springer
Abstract Novel coronavirus disease 2019 (COVID-19) has resulted in a global pandemic
and is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Several …

CD147-spike protein is a novel route for SARS-CoV-2 infection to host cells

KE Wang, W Chen, Z Zhang, Y Deng, JQ Lian… - Signal transduction and …, 2020 - nature.com
In face of the everlasting battle toward COVID-19 and the rapid evolution of SARS-CoV-2, no
specific and effective drugs for treating this disease have been reported until today …

Counter-regulatory renin–angiotensin system in cardiovascular disease

M Paz Ocaranza, JA Riquelme, L García… - Nature Reviews …, 2020 - nature.com
The renin–angiotensin system is an important component of the cardiovascular system.
Mounting evidence suggests that the metabolic products of angiotensin I and II—initially …

SARS-CoV-2 invades host cells via a novel route: CD147-spike protein

K Wang, W Chen, YS Zhou, JQ Lian, Z Zhang, P Du… - biorxiv, 2020 - biorxiv.org
Currently, COVID-19 caused by severe acute respiratory syndrome coronavirus 2 (SARS-
CoV-2) has been widely spread around the world; nevertheless, so far there exist no specific …

[HTML][HTML] The ACE2/angiotensin-(1–7)/MAS axis of the renin-angiotensin system: focus on angiotensin-(1–7)

RAS Santos, WO Sampaio, AC Alzamora… - Physiological …, 2017 - journals.physiology.org
The renin-angiotensin system (RAS) is a key player in the control of the cardiovascular
system and hydroelectrolyte balance, with an influence on organs and functions throughout …

Hypertension and COVID-19: current evidence and perspectives

G Gallo, V Calvez, C Savoia - High Blood Pressure & Cardiovascular …, 2022 - Springer
Abstract Coronavirus disease 2019 (COVID-19) outbreak, caused by severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2), represents a real challenge for health …

Role of the ACE2/angiotensin 1–7 axis of the renin–angiotensin system in heart failure

VB Patel, JC Zhong, MB Grant, GY Oudit - Circulation research, 2016 - Am Heart Assoc
Heart failure (HF) remains the most common cause of death and disability, and a major
economic burden, in industrialized nations. Physiological, pharmacological, and clinical …

The vasoprotective axes of the renin-angiotensin system: physiological relevance and therapeutic implications in cardiovascular, hypertensive and kidney diseases

XC Li, J Zhang, JL Zhuo - Pharmacological research, 2017 - Elsevier
The renin-angiotensin system (RAS) is undisputedly one of the most prominent endocrine
(tissue-to-tissue), paracrine (cell-to-cell) and intracrine (intracellular/nuclear) vasoactive …

Hypertension, a moving target in COVID-19: current views and perspectives

C Savoia, M Volpe, R Kreutz - Circulation Research, 2021 - Am Heart Assoc
Coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2) associates with a considerable high rate of mortality and …