Neurons affected in a wide variety of unrelated adult-onset neurodegenerative diseases
(AONDs) typically exhibit a “dying back” pattern of degeneration, which is characterized by …

Post-transcriptional control of mRNA trafficking and metabolism plays a critical role in the
actualization and fine tuning of the genetic program of cells, both in development and in …

RNA-binding proteins (RBPs) bind to and post-transcriptionally regulate the stability of
mRNAs. La-related protein 1 (LARP1) is a conserved RBP that interacts with poly-A-binding …

An emerging molecular understanding of RNA alkylation and its removal is transforming our
knowledge of RNA biology and its interplay with cancer chemotherapy responses. DNA …

Peroxisome proliferator‐activated receptors (PPAR)‐α and‐γ in astrocytes play important
roles in inflammatory brain pathologies. Understanding the regulation of both activity and …

Ribonucleoprotein complexes involved in pre-mRNA splicing and mRNA decay are often
regulated by phosphorylation of RNA-binding proteins. Cells use phosphorylation …

During lytic Kaposi's sarcoma-associated herpesvirus (KSHV) infection, the viral
endonuclease SOX promotes widespread degradation of cytoplasmic messenger RNA …

Cell fate is shaped by a unique gene expression program, which reflects the concerted
action of multilayered precise regulation. Substantial research attention has been paid to the …

Regional differences in posttranscriptional mechanisms may influence in vivo protein
densities. The association of positron emission tomography (PET) imaging data from 112 …

Over 10% of genetic diseases are caused by mutations that introduce a premature
termination codon in protein-coding mRNA. Nonsense-mediated mRNA decay (NMD) is an …