The major innate immune cell types involved in tuberculosis (TB) infection are
macrophages, dendritic cells (DCs), neutrophils and natural killer (NK) cells. These immune …

Infection with Mycobacterium tuberculosis causes> 1.5 million deaths worldwide annually.
Innate immune cells are the first to encounter M. tuberculosis, and their response dictates …

Mycobacterium tuberculosis, a major global health threat, replicates in macrophages in part
by inhibiting phagosome–lysosome fusion, until interferon-γ (IFNγ) activates the …

NOD1 and NOD2 are related intracellular sensors of bacterial peptidoglycan and belong to
the Nod-like receptor (NLR) family of innate immune proteins that play fundamental and …

The innate immune system in vertebrates and invertebrates relies on conserved receptors
and ligands, and pathways that can rapidly initiate the host response against microbial …

Host immune response against Mycobacterium tuberculosis is mediated by cellular
immunity, in which cytokines and Th1 cells play a critical role. In the process of control of the …

Effectively treating infectious diseases often requires a multi-step approach to target different
components involved in disease pathogenesis. Similarly, the COVID-19 pandemic has …

Sensing intracellular pathogens is a process mediated by innate immune cells that is crucial
for the induction of inflammatory processes and effective adaptive immune responses …

From plants to humans, the ability to control infection at the level of an individual cell—a
process termed cell-autonomous immunity—equates firmly with survival of the species …

Tuberculosis (TB) is one of the oldest known human diseases and is transmitted by the
bacteria Mycobacterium tuberculosis (Mtb). TB has a rich history with evidence of TB …