Although classically appreciated for their role as the powerhouse of the cell, the metabolic functions of mitochondria reach far beyond bioenergetics. In this Review, we discuss how …
Redox homeostasis is an essential requirement of the biological systems for performing various normal cellular functions including cellular growth, differentiation, senescence …
VV Pak, D Ezeriņa, OG Lyublinskaya, B Pedre… - Cell metabolism, 2020 - cell.com
Summary Hydrogen peroxide (H 2 O 2) is a key redox intermediate generated within cells. Existing probes for H 2 O 2 have not solved the problem of detection of the ultra-low …
E Panieri, MM Santoro - Cell death & disease, 2016 - nature.com
Tumor cells harbor genetic alterations that promote a continuous and elevated production of reactive oxygen species. Whereas such oxidative stress conditions would be harmful to …
K Chen, Y Li, X Zhang, R Ullah, J Tong, Y Shen - Cell death & disease, 2022 - nature.com
Abstract Phosphatidylinositol 3 kinase (PI3K)/AKT (also called protein kinase B, PKB) signalling regulates various cellular processes, such as apoptosis, cell proliferation, the cell …
X Liang, JM Zhou - Annual review of plant biology, 2018 - annualreviews.org
Receptor kinases (RKs) are of paramount importance in transmembrane signaling that governs plant reproduction, growth, development, and adaptation to diverse environmental …
M Schieber, NS Chandel - Current biology, 2014 - cell.com
Oxidative stress refers to elevated intracellular levels of reactive oxygen species (ROS) that cause damage to lipids, proteins and DNA. Oxidative stress has been linked to a myriad of …
Metabolic rewiring and the consequent production of reactive oxygen species (ROS) are necessary to promote tumorigenesis. At the nexus of these cellular processes is the aberrant …
H Solleiro-Villavicencio… - Frontiers in cellular …, 2018 - frontiersin.org
In a state of oxidative stress, there is an increase of reactive species, which induce an altered intracellular signaling, leading to dysregulation of the inflammatory response. The …