RONS and oxidative stress: An overview of basic concepts

AK Aranda-Rivera, A Cruz-Gregorio… - Oxygen, 2022 - mdpi.com
Oxidative stress (OS) has greatly interested the research community in understanding
damaging processes occurring in cells. OS is triggered by an imbalance between reactive …

The multifaceted contributions of mitochondria to cellular metabolism

JB Spinelli, MC Haigis - Nature cell biology, 2018 - nature.com
Although classically appreciated for their role as the powerhouse of the cell, the metabolic
functions of mitochondria reach far beyond bioenergetics. In this Review, we discuss how …

The multifaceted role of reactive oxygen species in tumorigenesis

A Kirtonia, G Sethi, M Garg - Cellular and Molecular Life Sciences, 2020 - Springer
Redox homeostasis is an essential requirement of the biological systems for performing
various normal cellular functions including cellular growth, differentiation, senescence …

[HTML][HTML] Ultrasensitive genetically encoded indicator for hydrogen peroxide identifies roles for the oxidant in cell migration and mitochondrial function

VV Pak, D Ezeriņa, OG Lyublinskaya, B Pedre… - Cell metabolism, 2020 - cell.com
Summary Hydrogen peroxide (H 2 O 2) is a key redox intermediate generated within cells.
Existing probes for H 2 O 2 have not solved the problem of detection of the ultra-low …

ROS homeostasis and metabolism: a dangerous liason in cancer cells

E Panieri, MM Santoro - Cell death & disease, 2016 - nature.com
Tumor cells harbor genetic alterations that promote a continuous and elevated production of
reactive oxygen species. Whereas such oxidative stress conditions would be harmful to …

The role of the PI3K/AKT signalling pathway in the corneal epithelium: recent updates

K Chen, Y Li, X Zhang, R Ullah, J Tong, Y Shen - Cell death & disease, 2022 - nature.com
Abstract Phosphatidylinositol 3 kinase (PI3K)/AKT (also called protein kinase B, PKB)
signalling regulates various cellular processes, such as apoptosis, cell proliferation, the cell …

Receptor-like cytoplasmic kinases: central players in plant receptor kinase–mediated signaling

X Liang, JM Zhou - Annual review of plant biology, 2018 - annualreviews.org
Receptor kinases (RKs) are of paramount importance in transmembrane signaling that
governs plant reproduction, growth, development, and adaptation to diverse environmental …

[HTML][HTML] ROS function in redox signaling and oxidative stress

M Schieber, NS Chandel - Current biology, 2014 - cell.com
Oxidative stress refers to elevated intracellular levels of reactive oxygen species (ROS) that
cause damage to lipids, proteins and DNA. Oxidative stress has been linked to a myriad of …

Phosphoinositide 3-kinase/Akt signaling and redox metabolism in cancer

N Koundouros, G Poulogiannis - Frontiers in oncology, 2018 - frontiersin.org
Metabolic rewiring and the consequent production of reactive oxygen species (ROS) are
necessary to promote tumorigenesis. At the nexus of these cellular processes is the aberrant …

Effect of Chronic Oxidative Stress on Neuroinflammatory Response Mediated by CD4+T Cells in Neurodegenerative Diseases

H Solleiro-Villavicencio… - Frontiers in cellular …, 2018 - frontiersin.org
In a state of oxidative stress, there is an increase of reactive species, which induce an
altered intracellular signaling, leading to dysregulation of the inflammatory response. The …