Clinical and preclinical studies have demonstrated that depression, one of the most common
psychiatric illnesses, is associated with reduced levels of neurotrophic factors, including …

The structure of the brain is constantly changing from birth throughout the lifetime, meaning
that normal aging, free from dementia, is associated with structural brain changes. This …

Late adulthood is associated with increased hippocampal atrophy and dysfunction. Although
there are multiple paths by which hippocampal deterioration occurs in late life, the authors …

Hippocampal volume shrinks in late adulthood, but the neuromolecular factors that trigger
hippocampal decay in aging humans remains a matter of speculation. In rodents, brain …

Brain-derived neurotrophic factor (BDNF) has a primary role in neuronal development,
differentiation and plasticity in both the developing and adult brain. A single-nucleotide …

The rate of age-associated cognitive decline varies considerably between individuals. It is
important, both on a societal and individual level, to investigate factors that underlie these …

Twin studies suggest that variation in human brain volume is genetically influenced. The
genes involved in human brain volume variation are still largely unknown, but several …

Context Brain-derived neurotrophic factor (BDNF) modulates hippocampal plasticity, which
is believed to be altered in patients with major depression. Objective To examine the effect …

The neurotrophic hypothesis of depression proposes that reduced levels of brain-derived
neurotrophic factor (BDNF) and vascular endothelial growth factor (VEGF) contribute to …

Brain-derived neurotrophic factor (BDNF) is important to brain functions such as plasticity
and repair. A single nucleotide polymorphism for this growth factor, val66met, is common …