Drug consumption is driven by a drug's pharmacological effects, which are experienced as
rewarding, and is influenced by genetic, developmental, and psychosocial factors that …

Chronic stress-induced emotional disorders like anxiety and depression involve imbalances
between the excitatory glutamatergic system and the inhibitory GABAergic system in the …

Anxiety disorders that develop in adolescence represent a significant burden and are
particularly challenging to treat, due in no small part to the high occurrence of relapse in this …

Adolescence is a time of significant neurocognitive development. Prolonged maturation of
prefrontal cortex (PFC) through adolescence has been found to support improvements in …

Adolescence is a window of vulnerability to environmental factors such as chronic stress that
can disrupt brain development and cause long-lasting behavioral dysfunction, as seen in …

Depression is more prevalent among adolescents than adults, but the underlying
mechanisms remain largely unknown. Using a subthreshold chronic stress model, here we …

Differential racial and socioeconomic disparities in dementia incidence across income
groups and their underlying mechanisms remain largely unknown. A retrospective cohort …

Stress can predispose to depressive episodes, yet the molecular mechanisms regulating the
transition from the initial stress response to a persistent pathological depressive state remain …

Stress is a major risk factor for neurodevelopmental and neuropsychiatric disorders, with the
capacity to impact susceptibility to disease as well as long-term neurobiological and …

The extracellular space is occupied by a complex network of proteins creating a mesh-like
assembly known as the extracellular matrix (ECM). ECM assembles into dense net-like …