Rethinking pioglitazone as a cardioprotective agent: a new perspective on an overlooked drug
Since 1985, the thiazolidinedione pioglitazone has been widely used as an insulin
sensitizer drug for type 2 diabetes mellitus (T2DM). Although fluid retention was early …
sensitizer drug for type 2 diabetes mellitus (T2DM). Although fluid retention was early …
The impact of diet on asthma and allergic diseases
The incidence of allergic diseases is increasing, both in developed and developing
countries, concomitantly with the rise in living standards and the adoption of a'western …
countries, concomitantly with the rise in living standards and the adoption of a'western …
From molecular action to physiological outputs: peroxisome proliferator-activated receptors are nuclear receptors at the crossroads of key cellular functions
JN Feige, L Gelman, L Michalik, B Desvergne… - Progress in lipid …, 2006 - Elsevier
Peroxisome proliferator-activated receptors (PPARs) compose a family of three nuclear
receptors which act as lipid sensors to modulate gene expression. As such, PPARs are …
receptors which act as lipid sensors to modulate gene expression. As such, PPARs are …
PPARγ and the Innate Immune System Mediate the Resolution of Inflammation
A Croasdell, PF Duffney, N Kim, SH Lacy… - PPAR …, 2015 - Wiley Online Library
The resolution of inflammation is an active and dynamic process, mediated in large part by
the innate immune system. Resolution represents not only an increase in anti‐inflammatory …
the innate immune system. Resolution represents not only an increase in anti‐inflammatory …
Compositionally and functionally distinct sinus microbiota in chronic rhinosinusitis patients have immunological and clinically divergent consequences
Background Chronic rhinosinusitis (CRS) is a heterogeneous disease characterized by
persistent sinonasal inflammation and sinus microbiome dysbiosis. The basis of this …
persistent sinonasal inflammation and sinus microbiome dysbiosis. The basis of this …
Peroxisome proliferator-activated receptors and inflammation
LA Moraes, L Piqueras, D Bishop-Bailey - Pharmacology & therapeutics, 2006 - Elsevier
Peroxisome proliferator-activated receptors (PPARs) are members of the nuclear hormone
receptors family. PPARs are a family of 3 ligand-activated transcription factors: PPARα …
receptors family. PPARs are a family of 3 ligand-activated transcription factors: PPARα …
An M1-like macrophage polarization in decidual tissue during spontaneous preterm labor that is attenuated by rosiglitazone treatment
Decidual macrophages are implicated in the local inflammatory response that accompanies
spontaneous preterm labor/birth; however, their role is poorly understood. We hypothesized …
spontaneous preterm labor/birth; however, their role is poorly understood. We hypothesized …
Nuclear hormone receptors enable macrophages and dendritic cells to sense their lipid environment and shape their immune response
A key issue in the immune system is to generate specific cell types, often with opposing
activities. The mechanisms of differentiation and subtype specification of immune cells such …
activities. The mechanisms of differentiation and subtype specification of immune cells such …
Modulation of inflammation and immunity by dietary conjugated linoleic acid
M Viladomiu, R Hontecillas… - European journal of …, 2016 - Elsevier
Conjugated linoleic acid (CLA) is a mixture of positional and geometric isomers of linoleic
acid. This family of polyunsaturated fatty acids has drawn significant attention in the last …
acid. This family of polyunsaturated fatty acids has drawn significant attention in the last …
Nrf2-regulated PPARγ expression is critical to protection against acute lung injury in mice
Rationale: The NF-E2 related factor 2 (Nrf2)–antioxidant response element (ARE) pathway
is essential for protection against oxidative injury and inflammation including hyperoxia …
is essential for protection against oxidative injury and inflammation including hyperoxia …