DMRT1: an ancient sexual regulator required for human gonadogenesis

D Zarkower, MW Murphy - Sexual Development, 2022 - karger.com
Transcriptional regulators related to the invertebrate sexual regulators doublesex and mab-3
occur throughout metazoans and control sex in most animal groups. Seven of these DMRT …

Zinc Fingers in Caenorhabditis elegans: Finding Families and Probing Pathways

ND Clarke, JM Berg - Science, 1998 - science.org
More than 3 percent of the protein sequences inferred from the Caenorhabditis elegans
genome contain sequence motifs characteristic of zinc-binding structural domains, and of …

Evidence for evolutionary conservation of sex-determining genes

CS Raymond, CE Shamu, MM Shen, KJ Seifert… - Nature, 1998 - nature.com
Most metazoans occur as two sexes. Surprisingly, molecular analyses have hitherto
indicated that sex-determining mechanisms differ completely between phyla. Here we …

Expression of Dmrt1 in the genital ridge of mouse and chicken embryos suggests a role in vertebrate sexual development

CS Raymond, JR Kettlewell, B Hirsch, VJ Bardwell… - Developmental …, 1999 - Elsevier
Sex-determining mechanisms are highly variable between phyla. Only one example has
been found in which structurally and functionally related genes control sex determination in …

The regulation and evolution of a genetic switch controlling sexually dimorphic traits in Drosophila

TM Williams, JE Selegue, T Werner, N Gompel, A Kopp… - Cell, 2008 - cell.com
Sexually dimorphic traits play key roles in animal evolution and behavior. Little is known,
however, about the mechanisms governing their development and evolution. One recently …

A region of human chromosome 9p required for testis development contains two genes related to known sexual regulators

CS Raymond, ED Parker, JR Kettlewell… - Human molecular …, 1999 - academic.oup.com
Deletion of the distal short arm of chromosome 9 (9p) has been reported in a number of
cases to be associated with gonadal dysgenesis and XY sex reversal, suggesting that this …

AY chromosome-linked genome editor for efficient population suppression in the malaria vector Anopheles gambiae

I Tolosana, K Willis, M Gribble, L Phillimore… - Nature …, 2025 - nature.com
Genetic control–the deliberate introduction of genetic traits to control a pest or vector
population–offers a powerful tool to augment conventional mosquito control tools that have …

Rapid Evolution of Sex Pheromone-Producing Enzyme Expression in Drosophila

TR Shirangi, HD Dufour, TM Williams, SB Carroll - PLoS biology, 2009 - journals.plos.org
A wide range of organisms use sex pheromones to communicate with each other and to
identify appropriate mating partners. While the evolution of chemical communication has …

Developmental Link between Sex and Nutrition; doublesex Regulates Sex-Specific Mandible Growth via Juvenile Hormone Signaling in Stag Beetles

H Gotoh, H Miyakawa, A Ishikawa, Y Ishikawa… - PLoS …, 2014 - journals.plos.org
Sexual dimorphisms in trait expression are widespread among animals and are especially
pronounced in ornaments and weapons of sexual selection, which can attain exaggerated …

The Drosophila takeout gene is regulated by the somatic sex-determination pathway and affects male courtship behavior

B Dauwalder, S Tsujimoto, J Moss… - Genes & …, 2002 - genesdev.cshlp.org
The Drosophila somatic sex-determination regulatory pathway has been well studied, but
little is known about the target genes that it ultimately controls. In a differential screen for sex …