Quorum sensing is a cell-to-cell communication system that exists widely in the microbiome
and is related to cell density. The high-density colony population can generate a sufficient …

Interference with quorum sensing (QS) represents an antivirulence strategy with significant
promise for the treatment of bacterial infections and a new approach for restoring antibiotic …

The cyclooxygenase-2 receptor is a therapeutic target for planning potential drugs with anti-
inflammatory activity. The selective cyclooxygenase-2 (COX-2) inhibitor rofecoxib was …

The increasing threat of antibiotic resistance and shrinking treatment options for infections
have pushed mankind into a difficult position. The looming threat of the return of the pre …

Bacterial biofilm is a community of bacteria that are embedded and structured in a self-
secreted extracellular matrix. An important clinical-related characteristic of bacterial biofilms …

Antibiotic resistance is one of the most important concerns in global health today. A growing
number of infections are becoming harder to treat with conventional drugs and fewer new …

The rapid development of multi-drug resistant (MDR) pathogens adds urgency to search for
novel and safe drugs having promising action on new and re-emerging infectious …

Pseudomonas aeruginosa relies on its complex cellular regulatory network to produce a
series of virulence factors and to cause various acute and chronic infections in a wide range …

The majority of pathogenic bacteria utilize cell to cell communication mechanisms to
regulate the cell density and expression of virulence factors. Therefore, quorum sensing …

The emergence of multidrug-resistant (MDR) bacterial strains in the last decade is
astonishingly alarming. Many of the widely used antibiotics have failed to exhibit clinical …