PLK1 is an evolutionary conserved Ser/Thr kinase that is best known for its role in cell cycle
regulation and is expressed predominantly during the G2/S and M phase of the cell cycle …

For decades, KRAS mutant lung adenocarcinomas (LUAD) have been refractory to
therapeutic strategies based on personalized medicine owing to the complexity of designing …

The laboratory mouse ranks among the most important experimental systems for biomedical
research and molecular reference maps of such models are essential informational tools …

Patient-derived organoids (PDOs) are widely heralded as a drug-screening platform to
develop new anti-cancer therapies. Here, we use a drug-repurposing library to screen PDOs …

Kinase inhibitors (KIs) are important cancer drugs but often feature polypharmacology that is
molecularly not understood. This disconnect is particularly apparent in cancer entities such …

RAS proteins are conserved guanosine triphosphate (GTP) hydrolases (GTPases) that act
as molecular binary switches and play vital roles in numerous cellular processes. Upon GTP …

Ewing sarcoma (EWS) is a pediatric malignancy driven by the EWSR1-FLI1 fusion protein
formed by the chromosomal translocation t (11; 22). The small molecule TK216 was …

Background While immune checkpoint blockade (ICB) is the current first-line treatment for
metastatic melanoma, it is effective for~ 52% of patients and has dangerous side effects. The …

Within the MAPK/RAS pathway, there exists a plethora of protein–protein interactions (PPIs).
For many years, scientists have focused efforts on drugging KRAS and its effectors in hopes …

Hepatocellular carcinoma (HCC) is one of the deadliest cancers with high mortality and poor
prognosis, and the investigation on new approaches and effective drugs for HCC therapy is …