Many oxidation–reduction (redox) enzymes, particularly oxygenases, have roles in reactions
that make and break C–C bonds. The list includes cytochrome P450 and other heme-based …

Abstract Aromatase (estrogen synthetase; EC 1.14. 14.1) catalyzes the demethylation of
androgens' carbon 19, producing phenolic 18-carbon estrogens. Aromatase is most widely …

Enzymes are complex biological catalysts and are critical to life. Most oxidations of
chemicals are catalyzed by cytochrome P450 (P450, CYP) enzymes, which generally utilize …

Cytochrome P450 enzymes catalyze a broad diversity of reactions, including well-
established transformations such as carbon and nitrogen hydroxylation, heteroatom …

Most clinically used drugs are metabolized in the body via oxidation, reduction, or hydrolysis
reactions, which are considered phase I reactions. Cytochrome P450 (P450) enzymes …

Ketones are an important class of molecules in synthetic and medicinal chemistry. Rapid
and modular synthesis of ketones remains in high demand. Described here is a nickel …

The Rh (III)-catalyzed C–H oxidative alkylation of aniline derivatives with readily available
secondary allyl alcohols using a pyrimidine-directing group, leading to the production of β …

Most cytochrome P450 (P450) oxidations are considered to occur with the active oxidant
being a perferryl oxygen (FeO3+, Compound I). However, a ferric peroxide (FeO2̅ …

The rhodium (III)-catalyzed site-selective C–H alkylation of various N-heterocycles, such as
indolines, carbazoles, and pyrroles with readily available allylic alcohols is described. This …

The selective cleavage of thermodynamically stable C (sp3)− C (sp3) single bonds is rare
compared to their ubiquitous formation. Herein, we describe a general methodology for such …