Impact of the Human Cell Atlas on medicine
JE Rood, A Maartens, A Hupalowska, SA Teichmann… - Nature medicine, 2022 - nature.com
Single-cell atlases promise to provide a 'missing link'between genes, diseases and
therapies. By identifying the specific cell types, states, programs and contexts where disease …
therapies. By identifying the specific cell types, states, programs and contexts where disease …
Adverse effects of COVID-19 mRNA vaccines: the spike hypothesis
Vaccination is a major tool for mitigating the coronavirus disease 2019 (COVID-19)
pandemic, and mRNA vaccines are central to the ongoing vaccination campaign that is …
pandemic, and mRNA vaccines are central to the ongoing vaccination campaign that is …
[HTML][HTML] Immune imprinting, breadth of variant recognition, and germinal center response in human SARS-CoV-2 infection and vaccination
During the SARS-CoV-2 pandemic, novel and traditional vaccine strategies have been
deployed globally. We investigated whether antibodies stimulated by mRNA vaccination …
deployed globally. We investigated whether antibodies stimulated by mRNA vaccination …
mRNA vaccines induce durable immune memory to SARS-CoV-2 and variants of concern
INTRODUCTION Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) mRNA
vaccines are highly effective at preventing infection and especially severe disease …
vaccines are highly effective at preventing infection and especially severe disease …
Lipid nanoparticles enhance the efficacy of mRNA and protein subunit vaccines by inducing robust T follicular helper cell and humoral responses
Adjuvants are critical for improving the quality and magnitude of adaptive immune
responses to vaccination. Lipid nanoparticle (LNP)-encapsulated nucleoside-modified …
responses to vaccination. Lipid nanoparticle (LNP)-encapsulated nucleoside-modified …
BNT162b2 vaccination induces durable SARS-CoV-2–specific T cells with a stem cell memory phenotype
G Guerrera, M Picozza, S D'Orso, R Placido… - Science …, 2021 - science.org
Vaccination against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is
effective in preventing hospitalization from severe COVID-19. However, multiple reports of …
effective in preventing hospitalization from severe COVID-19. However, multiple reports of …
Durability of BNT162b2 vaccine against hospital and emergency department admissions due to the omicron and delta variants in a large health system in the USA: a …
SY Tartof, JM Slezak, L Puzniak, V Hong… - The Lancet …, 2022 - thelancet.com
Background The duration of protection against the omicron (B. 1.1. 529) variant for current
COVID-19 vaccines is not well characterised. Vaccine-specific estimates are especially …
COVID-19 vaccines is not well characterised. Vaccine-specific estimates are especially …
Mechanisms of innate and adaptive immunity to the Pfizer-BioNTech BNT162b2 vaccine
Despite the success of the BNT162b2 mRNA vaccine, the immunological mechanisms that
underlie its efficacy are poorly understood. Here we analyzed the innate and adaptive …
underlie its efficacy are poorly understood. Here we analyzed the innate and adaptive …
Heterologous infection and vaccination shapes immunity against SARS-CoV-2 variants
CJ Reynolds, JM Gibbons, C Pade, KM Lin… - Science, 2022 - science.org
The impact of the initial severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
infecting strain on downstream immunity to heterologous variants of concern (VOCs) is …
infecting strain on downstream immunity to heterologous variants of concern (VOCs) is …
Spheromers reveal robust T cell responses to the Pfizer/BioNTech vaccine and attenuated peripheral CD8+ T cell responses post SARS-CoV-2 infection
T cells are a critical component of the response to SARS-CoV-2, but their kinetics after
infection and vaccination are insufficiently understood. Using" spheromer" peptide-MHC …
infection and vaccination are insufficiently understood. Using" spheromer" peptide-MHC …