Preterm birth (PTB) is defined as delivery before 37 weeks of gestation. Globally, 15 million
infants are born prematurely, putting these children at an increased risk of mortality and …

Known for nearly a century but through mechanisms that remain elusive, cells retain a
memory of inflammation that equips them to react quickly and broadly to diverse secondary …

During pregnancy, the primary function of the uterus is to be quiescent and not contract,
which allows the growing fetus to develop and mature. A uterine muscle layer, myometrium …

Infertility occurs in 15% of couples worldwide. Recurrent implantation failure (RIF) is one of
the major problems in in vitro fertilization and embryo transfer (IVF–ET) programs, and how …

The underlying mechanisms governing parturition remain largely elusive due to limited
knowledge of parturition preparation and initiation. Accumulated evidences indicate that …

The uterine myometrium expands and maintains contractile quiescence before parturition.
While the steroid hormone progesterone blocks labor, the role of progesterone signaling in …

Introduction Preterm birth is one of the major causes of neonatal morbidity and mortality
across the world. Both term and preterm labour are preceded by inflammatory activation in …

Despite the widespread use of oxytocin for induction of labor, mechanistic insights into
fetal/neonatal wellbeing are lacking because of the absence of an animal model that …

Myometrial contraction is stringently controlled throughout pregnancy and parturition.
Progesterone signaling, effecting through the progesterone receptor (PR), is pivotal in …

The onset of labour is a culmination of a series of highly coordinated and preparatory
physiological events that take place throughout the gestational period. In order to produce …