Many areas of modern technology are dependent on sensitive analytical techniques, and
this is particularly true for environmental science, medicine, pharmacy, and cellular biology …

Although anti-inflammatory drugs are among the most common class of marketed drugs,
chronic inflammatory conditions such as rheumatoid arthritis, multiple sclerosis or …

Purpose: To develop melanoma-targeted hollow gold nanospheres (HAuNS) and evaluate
their potential utility for selective photothermal ablation in melanoma. Experimental Design …

G protein coupled receptors are responsible for a wide variety of signaling responses in
diverse cell types. Despite major advances in the determination of structures of this class of …

Targeted nanoparticle-based delivery systems have been used extensively to develop
effective cancer theranostics. However, how targeting ligands affect extravascular transport …

Early reports on the identification of fluorescent probes for receptors date back to mid-1970s.
Fluorescent probes were initially used to visualize molecular targets in an analogous way to …

Fluorescently tagged drug molecules can be successfully employed to visualize the location
of their receptor target at the single-cell level. Furthermore, if their binding to the receptor is …

Fluorescence nanoscopy represented a breakthrough for the life sciences as it delivers 20–
30 nm resolution using far-field fluorescence microscopes. This resolution limit is not …

G protein-coupled receptors (GPCRs) play crucial roles in the ability of target organs to
respond to hormonal cues. GPCRs' activation mechanisms have long been considered as a …

For over three decades, the design of linear peptide ligands often has incorporated cyclic
constraints to improve potency, receptor selectivity, proteolytic stability and biodistribution. Its …