CGMP signaling in photoreceptor degeneration

S Li, H Ma, F Yang, X Ding - International Journal of Molecular Sciences, 2023 - mdpi.com
Photoreceptors in the retina are highly specialized neurons with photosensitive molecules in
the outer segment that transform light into chemical and electrical signals, and these signals …

Insights into Calpain Activation and Rho-ROCK Signaling in Parkinson's Disease and Aging

A Gathings, V Zaman, NL Banik, A Haque - Biomedicines, 2024 - mdpi.com
Parkinson's disease (PD), a progressive neurodegenerative disease, has no cure, and
current therapies are not effective at halting disease progression. The disease affects mid …

T-type voltage-gated channels, Na+/Ca2+-exchanger, and calpain-2 promote photoreceptor cell death in inherited retinal degeneration

J Yan, L Wang, QL Yang, QX Yang, X He… - Cell Communication and …, 2024 - Springer
Inherited retinal degenerations (IRDs) are a group of untreatable and commonly blinding
diseases characterized by progressive photoreceptor loss. IRD pathology has been linked to …

[HTML][HTML] Gene‒Environment Interaction Between CAST Gene and Eye-Rubbing in the Chinese Keratoconus Cohort Study: A Case-Only Study

S Yin, L Xu, K Yang, Q Fan, Y Gu, C Yin… - … & Visual Science, 2024 - tvst.arvojournals.org
Purpose: Keratoconus (KC), characterized by progressive corneal protrusion and thinning, is
a complex disease influenced by the combination of genetic and environmental factors. The …

Involvement of IGF1 in endoplasmic reticulum stress contributes to cataract formation through regulating Nrf2/NF-κB signaling

R Peng, H Lin, H Zhu, Y Zhang, T Bao, W Li… - Functional & Integrative …, 2023 - Springer
Endoplasmic reticulum (ER) stress is reportedly involved in the development of ophthalmic
diseases. This study aimed to investigate the role and potential mechanism of insulin-like …

Impaired activity and membrane association of most calpain-5 mutants causal for neovascular inflammatory vitreoretinopathy

JW Geddes, V Bondada, DE Croall… - … et Biophysica Acta (BBA …, 2023 - Elsevier
Neovascular inflammatory vitreoretinopathy (NIV) is a rare eye disease that ultimately leads
to complete blindness and is caused by mutations in the gene encoding calpain-5 (CAPN5) …

Autosomal dominant neovascular inflammatory vitreoretinopathy with CAPN5 c. 731T> C gene mutation; clinical management of a family cohort and review of the …

T Tabbaa, AA Mehra, NP Kesav, VB Mahajan… - Ophthalmic …, 2023 - Taylor & Francis
Background To report a cohort of patients with clinically and genetically diagnosed
autosomal dominant neovascular inflammatory vitreoretinopathy (ADNIV) and showcase the …

Protein Networks in Human Disease

KM Poluri, K Gulati, DK Tripathi, N Nagar - Protein-Protein Interactions …, 2023 - Springer
Anomalies in protein–protein interactions may lead to a diseased state, as many cellular
functions are sustained by such interactions. These abnormal situations usually arise when …

Calpain Activation Regulates Rho-ROCK Pathway in Parkinson's Disease

AJ Gathings - 2024 - medica-musc.researchcommons.org
Parkinson's disease (PD) is a progressive neurodegenerative disease resulting in difficulty
with motor coordination, balance, and speaking. Although the cause of PD remains …

Uloga kalpaina u šećernoj bolesti i njezinim komplikacijama

L Mlinac - 2024 - repository.biotech.uniri.hr
Sažetak Kalpaini su klasa koju čine 15 članova kalcijem aktiviranih nelizosomalnih
neutralnih proteaza koje utječu na širok raspon staničnih funkcija. Kalpaini su obično …