Molecular mechanisms underlying the dedifferentiation process of isolated hepatocytes and their cultures

G Elaut, T Henkens, P Papeleu… - Current drug …, 2006 - ingentaconnect.com
Primary hepatocytes and their cultures are a simple but versatile, well-controlled, and
relatively easy to handle in vitro system that is well-accepted for investigating xenobiotic …

Liver progenitor cells yield functional hepatocytes in response to chronic liver injury in mice

R Español–Suñer, R Carpentier, N Van Hul, V Legry… - Gastroenterology, 2012 - Elsevier
BACKGROUND & AIMS: Self-renewal of mature hepatocytes promotes homeostasis and
regeneration of adult liver. However, recent studies have indicated that liver progenitor cells …

Functional integration of hepatocytes derived from human mesenchymal stem cells into mouse livers

I Aurich, LP Mueller, H Aurich, J Luetzkendorf, K Tisljar… - Gut, 2007 - gut.bmj.com
Aims: At present, clinical success of hepatocyte transplantation as an alternative to whole
liver transplantation is hampered by the limited availability of suitable donor organs for the …

Generation, characterization and potential therapeutic applications of mature and functional hepatocytes from stem cells

Z Zhang, J Liu, Y Liu, Z Li, WQ Gao… - Journal of cellular …, 2013 - Wiley Online Library
Liver cancer is the sixth most common tumor in the world and the majority of patients with
this disease usually die within 1 year. The effective treatment for end‐stage liver disease …

Correlation between the Antimicrobial Activity and Metabolic Profiles of Cell Free Supernatants and Membrane Vesicles Produced by Lactobacillus reuteri DSM …

A Maccelli, S Carradori, V Puca, F Sisto, P Lanuti… - Microorganisms, 2020 - mdpi.com
The aim of the work is to assess the antimicrobial activities of Cell Free Supernatants (CFS)
and Membrane Vesicles (MVs), produced by Lactobacillus reuteri DSM 17938, versus Gram …

Cadmium suppresses the proliferation of piglet Sertoli cells and causes their DNA damage, cell apoptosis and aberrant ultrastructure

M Zhang, Z He, L Wen, J Wu, L Yuan, Y Lu… - Reproductive biology …, 2010 - Springer
Objective Very little information is known about the toxic effects of cadmium on somatic cells
in mammalian testis. The objective of this study is to explore the toxicity of cadmium on piglet …

Direct transdifferentiation of spermatogonial stem cells to morphological, phenotypic and functional hepatocyte-like cells via the ERK1/2 and Smad2/3 signaling …

Z Zhang, Y Gong, Y Guo, Y Hai, H Yang, S Yang… - Cell communication and …, 2013 - Springer
Background Severe shortage of liver donors and hepatocytes highlights urgent requirement
of extra-liver and stem cell source of hepatocytes for treating liver-related diseases. Here we …

Cell and tissue therapy for the treatment of chronic liver disease

Y Bram, DHT Nguyen, V Gupta, J Park… - Annual review of …, 2021 - annualreviews.org
Liver disease is an important clinical problem, impacting 600 million people worldwide. It is
the 11th-leading cause of death in the world. Despite constant improvement in treatment and …

Melamine causes apoptosis of rat kidney epithelial cell line (NRK‐52e cells) via excessive intracellular ROS (reactive oxygen species) and the activation of p38 MAPK …

C Guo, H Yuan, Z He - Cell biology international, 2012 - Wiley Online Library
There was an outbreak of urinary stones associated with consumption of melamine‐tainted
milk products in 2008 in China, leading to serious illness of many infants and even death …

Monitoring cultured rat hepatocytes using RNA-Seq in vitro

YT Hou, CC Wu, WT Wang, WT Yang, YH Liao… - International Journal of …, 2023 - mdpi.com
Compared to other techniques, RNA sequencing (RNA-Seq) has the advantage of having
details of the expression abundance of all transcripts in a single run. In this study, we used …