Abstract Infection with Human papillomaviruses (HPVs) leads to the development of a wide-
range of cancers, accounting for 5% of all human cancers. A prominent example is cervical …

Anal cancer accounts for approximately 2.4% of gastrointestinal malignancies. 1 Although
anal cancer is a rare tumor, its frequency is increasing, especially in highrisk groups. 2 …

Background: Curcumin, a natural polyphenol product of the plant Curcuma longa, has been
shown to inhibit the growth and progression of colorectal cancer; however, the anticancer …

Aim To investigate the cytotoxic effect of Peruvoside and mechanism of action in human
cancers. Main methods Cell viability was measured by MTT assay and the cell cycle arrest …

Colorectal cancer (CRC), as one of the most prevalent types of cancer worldwide, is still a
leading cause of cancer related mortality. There is an urgent need for more efficient …

Genetic alterations in the PIK3CA gene of the phosphoinositide 3-kinase (PI3K)/AKT
pathway have been found in many human tumors, but they have not been explored in …

Anal squamous cell carcinoma is a human papillomavirus-related disease, in which no
substantial advances in treatment have been made in over 40 years, especially for those …

Traditional treatment of cancer has been plagued by a number of obstacles, such as multiple
drug resistance, toxicity and financial constraints. In contrast, phytochemicals that modulate …

This was a phase II study of capecitabine in substitution of 5-fluorouracil (5-FU) in the
chemoradiotherapy regimen for patients with localized squamous cell carcinoma of the anal …

Background: A better understanding of the molecular profile of anal squamous cell
carcinomas (ASCCs) is necessary to consider new therapeutic approaches, and the …